Clusianon isomers and use thereof

Details Clusianon isomers and use thereof Clusianon isomers and use thereof

2006-11-14

2006-11-14

Witherspoon, Sikarl A. (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

C514S732000, C568S375000, C568S377000

Reexamination Certificate

active

07135501

ABSTRACT:
The invention relates to a clusianon isomer and to the use thereof, in particular as a pharmaceutical or medical active ingredient, in particular for producing medicaments for the prophylactic and/or therapeutic (curative) treatment of tumor or cancer diseases as well as viral diseases. The aforementioned compound can be used in cytostatics and antiviral agents (virostatics). Said compound acts, in particular, as a topoisomerase and telomerase inhibitor and as a regulator in the MAP kinase signal transduction. Said compound can thus intervene at the cellular level in the proliferation mechanism of tumor or cancer cells and viruses.

REFERENCES:
Oliveira et al. Floral resins ofClusiaSpp.: Chemical Composition and Biological Function.□□ Tetrahedron Letters, vol. 37 (36) pp. 6427-643, 1996.
Porto et al. Polyisoprenylated benzophenones fromClusiafloral resins. Phytochemistry, vol. 55, 2000, p. 755-768.
Henry et al. Prenylated Benzophenone Derivatives from CarribeanClusiaspecies (Guttiferae). Plukenetiones B-G and Xerophenone A. Tetrahedron, vol. 55, 1999, p. 1581-1596.

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