Closed-loop drug delivery system

Details Closed-loop drug delivery system Closed-loop drug delivery system

2006-09-19

2006-09-19

Kennedy, Sharon (Department: 3767)

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

C604S065000

Reexamination Certificate

active

07108680

ABSTRACT:
A delivery system for a drug or bioactive agent includes an implantable pump and a delivery conduit that may be implanted in an organ or other tissue (e.g., the central or the peripheral nervous system) of a subject. A sensor is also implanted, and a controller unit receives the sensor output and directs drug delivery from within the patient pump accordingly. The sensor directly measures a primary biochemical material or state in the tissue or organ system, and the monitoring unit effects closed loop feedback control of the pump to achieve a desired end. The end may be the regulation of metabolism or maintenance of a stable metabolic or other state, or may be treatment regimen, e.g., by delivery of a dosage level or distribution of a drug in specific brain or nervous an system tissue. The sensed material may be the agent itself, a metabolite, or a related native material, tissue state or condition.

REFERENCES:
patent: 4146029 (1979-03-01), Ellinwood, Jr.
patent: 4889407 (1989-12-01), Markle et al.
patent: 5305745 (1994-04-01), Zacouto
patent: 5474552 (1995-12-01), Palti
patent: 5511547 (1996-04-01), Markle et al.
patent: 5596988 (1997-01-01), Markle et al.
patent: 5676145 (1997-10-01), Bar-Lavie
patent: 5697899 (1997-12-01), Hillman et al.
patent: 5700897 (1997-12-01), Klainer et al.
patent: 5711315 (1998-01-01), Jerusalmy
patent: 5711316 (1998-01-01), Elsberry et al.
patent: 5720720 (1998-02-01), Laske et al.
patent: 5730125 (1998-03-01), Prutchi et al.
patent: 5730714 (1998-03-01), Guy et al.
patent: 5735814 (1998-04-01), Elsberry et al.
patent: 5782798 (1998-07-01), Rise
patent: 5792212 (1998-08-01), Weijand
patent: 5797898 (1998-08-01), Santini, Jr. et al.
patent: 5820622 (1998-10-01), Gross et al.
patent: 5978702 (1999-11-01), Ward et al.
patent: 6016449 (2000-01-01), Fischell et al.
patent: 6032059 (2000-02-01), Henning et al.
patent: 6122536 (2000-09-01), Sun et al.
patent: 6175752 (2001-01-01), Say et al.
patent: 6263237 (2001-07-01), Rise
patent: 6442413 (2002-08-01), Silver
patent: 6464687 (2002-10-01), Ishikawa et al.
patent: 6501983 (2002-12-01), Natarajan et al.
patent: 6558351 (2003-05-01), Steil et al.
patent: 2002/0138018 (2002-09-01), Lange et al.
patent: 1048264 (2000-11-01), None
patent: WO 02/11703 (2002-02-01), None
R.R. Lonser et al.,Direct Convective Delivery Of Macromolecules To The Spinal Cord, J. Neurosurg, 89:616-622 (1998).
M.Y. Chen et al.,Variables Affecting Convection-Enhanced Delivery To The Striatum: A Systematic Examination Of Rate Of Infusion, Cannula Size, Infusate Concentration, and Tissue-Cannula Sealing Time, J. Neurosurg, 90:315-320 (1999).
J.W. McDonald et al.,Repairing The Damaged Spinal Cord, Scientific American, p. 65-73 (Sep. 1999).
R. F. Service,Drug Deliver: Silicon Chips Find Role As In Vivo Pharmacist, News of the Week, 283:619 (Jan. 29, 1999).
M. Larkin,“Pharmacy” On A Microchip Looks Promising, The Lancet, 353:385 (Jan. 30, 1999).
S. Borman,Microchips Deliver On Command, C&EN, pp. 30 and 31 (Feb. 1, 1999).
D.N. Leff,Dime-Size, Programmable Drug-Delivery Microchip Passes Proof-of-Principle Test, Bio World Today, 10:18:1,3 (Jan. 28, 1999).
D. Stover,Pharmacy On A Chip, Popular Science, p. 33 (Apr. 1999).
J. O'Neil,Implantable Chip Offers Hope Of Simplifying Drug Regimens, Health & Fitness, N.Y. Times, Feb. 2, 1999, at D6 (NE).
J. T. Santini, Jr., et al,A Controlled-Release Microchip, Nature, 394, 335-338, (Jan. 28, 1999).

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