Cloning of the biosynthetic pathway for chlortetracycline and te

Details Cloning of the biosynthetic pathway for chlortetracycline and te Cloning of the biosynthetic pathway for chlortetracycline and te

1993-09-22

1996-12-31

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Protozoa, media therefor

4352523, 43525231, 43525232, 43525233, 4353201, 536 23223.7, C12N 121, C12N 1552, C12N 1576

Patent

active

055893856

ABSTRACT:
The present invention describes a purified and isolated nucleic acid molecule which encodes for the biosynthetic pathway of tetracycline, chlortetracycline or an analogue thereof. The invention relates to the isolation and cloning of the nucleic acid molecule in an isolated fragment from Streptomyces aureofaciens and the expression of the biosynthetic gene in a heterologous host such as Streptomyces lividans.

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Rao et al., Cosmid Shuttle Vectors for Cloning and Analysis of Streptomyces DNA, Methods in Enzymology, Academic Press, 1987, vol. 153, pp. 166-198.

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