Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1987-07-21
1990-02-13
Warden, Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436524, 436528, 436538, 436547, 436548, 436811, 436815, 530387, 530388, 935110, G01N 3300, G01N 3353
Patent
active
049006622
ABSTRACT:
Methods and reagents for early detection of myocardial infarction determine the level of CK-MM.sub.A and the level of the combined CK-MM.sub.A and CK-MM.sub.B in a serum sample. From these measurements, the time of the acute phase can be more accurately determined. Novel anti-(CK-MM.sub.A) antibodies, anti-(CK-MM.sub.B) antibodies, anti-(CK-MM.sub.(A+B)) antibodies, labeled and insolubilized derivatives of these antibodies, labeled CK-MM isoforms, and kits containing one or more of these reagents are also described.
REFERENCES:
patent: 4237219 (1980-12-01), Roberts
patent: 4260678 (1981-04-01), Lepp et al.
patent: 4353982 (1982-10-01), Gomez et al.
patent: 4624916 (1986-11-01), Shah et al.
Grace, A. M. et al, "Sensitive Quantification of Isoforms of Canine MM Creatine Kinase", Anal. Biochem. 149, 209-217 (1985).
Morison et al, Clin. Chem. 34: 535-538 (1988).
Anchin Gerald M.
Shah Vipin D.
Yen Shing-Erh
International Immunoassay Laboratories, Inc.
Terlizzi Laura
Wagner Richard
Walker William B.
Warden Robert J.
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