Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme sub

Details Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme sub Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme sub

1989-06-12

1992-04-14

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 173, 536 88, 536 8, 435 97, 435 23, 435 22, 435 14, C12Q 137, C12Q 140, C07H 1524, C08B 3700

Patent

active

051049805

ABSTRACT:
Chromogenic enzyme substrate compounds comprising a dibenz[b,e][1,4]oxazepinone or dibenzo[b,e][1,4]thiazepinone nucleus having an enzyme-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid. The substrate compounds are, in general, highly soluble in aqueous media and only slightly colored, and produce, upon enzyme cleavage, a chromogen exhibiting a large change in absorbance and a pKa below 7. Such substrates find use as indicators for the determination of enzyme analytes and enzymes used as markers in a variety of assays, including immunoassays.

REFERENCES:
patent: 4321364 (1982-03-01), McCleary
patent: 4716222 (1987-12-01), Wallenfels et al.
patent: 4932871 (1990-06-01), Bell et al.
Graan et al; "Analytical Biochemistry" (144); 193-198 (1985).

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