Method of preparation of a composition having a base of 99.sup.m

Details Method of preparation of a composition having a base of 99.sup.m Method of preparation of a composition having a base of 99.sup.m

1974-03-26

1976-01-06

Sebastian, Leland A.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 206 84, 250303, 424128, A61k 2704

Patent

active

039313964

ABSTRACT:
A method for preparing a pyrophosphate-tin composition labelled with 99.sup.m technetium for medical diagnosis by scintigraphy, especially bone scintigraphy. A pyrophosphate solution and a freshly prepared stannous chloride solution are mixed together and then neutralized to a pH within the range of 5 to 7, the mixture is eventually lyophilized in order to obtain a pyrophosphate-tin complex in powder form which is then mixed with a solution containing 99.sup.m Tc, the last-mentioned final step of the method being carried out at the moment of use. The complex has a pyrophosphate-tin molecular ratio of at least 30.

REFERENCES:
Subramanian et al., Radiology, Vol. 99, No. 1, pp. 192 to 196, (Apr. 1971).

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