Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-05-21
2008-11-25
Dentz, Bernard (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S220000, C549S405000, C514S100000
Reexamination Certificate
active
07456214
ABSTRACT:
Chrome compounds have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.
REFERENCES:
patent: 4133814 (1979-01-01), Jones et al.
patent: 4656187 (1987-04-01), Black et al.
patent: 4737517 (1988-04-01), della Valle et al.
patent: 5532382 (1996-07-01), Carlson et al.
patent: 5596106 (1997-01-01), Cullinan et al.
patent: 5886025 (1999-03-01), Pinney
patent: 5952350 (1999-09-01), Cullinan et al.
patent: 5958916 (1999-09-01), Bryant et al.
patent: 6162930 (2000-12-01), Pinney et al.
patent: 6277879 (2001-08-01), Xu et al.
patent: 6291456 (2001-09-01), Stein et al.
patent: 6331562 (2001-12-01), Bhagwat et al.
patent: 6350777 (2002-02-01), Pinney et al.
patent: 6573219 (2003-06-01), Linker et al.
patent: 6593374 (2003-07-01), Pinney et al.
patent: 2002/0161245 (2002-10-01), Huang
patent: 2003/0176494 (2003-09-01), Xu et al.
patent: 1 028 110 (2000-08-01), None
patent: 63-213503 (1988-09-01), None
patent: WO 96/40137 (1996-12-01), None
patent: WO 98/39323 (1998-09-01), None
patent: WO 99/34788 (1999-07-01), None
patent: WO 01/19794 (2001-03-01), None
patent: WO 02/060872 (2001-08-01), None
patent: WO 01/68654 (2001-09-01), None
patent: WO 01/77093 (2001-10-01), None
patent: WO 01/79180 (2001-10-01), None
patent: WO 01/81288 (2001-11-01), None
patent: WO 03/096982 (2003-11-01), None
patent: WO 03/105842 (2003-12-01), None
Bellassoued-Fargeau et al. J. Heterocyclic Chem., 22:45-46 (1985 ).
Koga, H et al ‘Preparation of benzopyran derivatives as potassium channel activators’ CA 117:7803 (1992).
O'Donnell RWH et al ‘Synthesis of rotenone and its derivatives. IX.’ CA 30:36771 (1936).
Butenandt, A et al ‘Vegetable, fish and insect poinons. IV> Constituents of varieties of Derris and Tephrosia. [Constitution of deguelin, tephrosin and toxicarol]’ CA 26:36536 (1932).
Chemical Abstracts 123:270364, RN 169227-65-0.
Bailly, et al.,J. Med. Chem., 46:5437-5444 (2003).
Boyd, et al.,Drug Dev. Res., 34:91-109 (1995).
Churcher, et al.,J. Am. Chem. Soc., 120:13350-10358 (1998).
Clive, et al.,J. Am. Chem. Soc., 120:10332-10349 (1998).
Cushman, et al.,J. Med. Chem., 38:2041-2049 (1995).
Cushman, et al.,J. Med. Chem., 40:2323-2334 (1997).
D'Amato, et al.,Proc. Natl. Acad. Sci. USA, 91:3964-3968 (1994).
Flynn, et al.,Organic Lett., 3(5):651-654 (2001).
Grese, et al.,J. Med. Chem., 40: 146-167 (1997).
Hamel, et al., Biochem., 35(4):1304-1310 (1996).
Jones, et al.,J. Med. Chem., 27:1057-1066 (1984).
Mullica, et al.,J. Chem. Cryst., 28(4):289-295 (1998).
Myers, et al.,J. Am. Chem. Soc., 119(26):6072-6094 (1997).
Palkowitz, et al.,J. Med. Chem., 40(10):1407-1416 (1997).
Pinney, et al.,Bioorg. Med. Chem. Lett., 9:1081-1086 (1999).
Arthasary Phyllis
Chaplin David J.
Edvardsen Klaus
Pinney Kevin G.
Shirali Anupama
Baylor University
Dentz Bernard
OXiGENE, Inc.
LandOfFree
Chromene-containing compounds with anti-tubulin and vascular... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chromene-containing compounds with anti-tubulin and vascular..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chromene-containing compounds with anti-tubulin and vascular... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4023127