Chordin compositions

Details Chordin compositions Chordin compositions

1998-08-04

1999-11-16

Kemmerer, Elizabeth

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 691, C07K 1446, C12P 2100

Patent

active

059860561

ABSTRACT:
Purified chordin proteins and processes for producing them are disclosed. DNA molecules encoding the chordin proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well for treatment of disorders and defects to tissue which include epidermis, nerve, muscle, including cardiac muscle, and othe tissues and wounds, and organs such as liver, brain, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction inhibition of growth and/or differentiation of undifferentiated embryonic and stem cells. The proteins may be complexed with other proteins, particularly members of the transforming growth factor-beta superfamily of proteins.

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