Vesicle trafficking protein

Details Vesicle trafficking protein Vesicle trafficking protein

1998-11-02

1999-11-16

Kemmerer, Elizabeth

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1446

Patent

active

059860570

ABSTRACT:
The present invention provides a human vesicle trafficking protein (HVTP) and polynucleotides which identify and encode HVTP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing HVTP and for treating or preventing disorders associated with expression of HVTP.

REFERENCES:
Dascher, R. et al., "Identification and Structure of Four Yeast Genes (SLY) that are able to Suppress the Functional Loss of YPT1, a Member of the RAS Superfamily", Molecular and Cellular Biology, vol. 11, (1991), pp. 872-885.
Hiller, L. et al., "Homo Sapiens Clone (358555)", (1996) Acession #W96377.
Newman, A.P. et al., "BET1, BOS1, and SEC22 are Members of a Group of Interacting Yeast Genes Required for Transport from the Endoplasmic Reticulum to the Golgi Complex", Molecular and Cellular Biology, vol. 10, No. 7, pp. 3405-3414.
Ausubel, F.M., "Using Synthetic Oligonucleotides as Probes", Current Protocol in Molecular Biology, vol. 1, (1988), pp. 6.4.01-6.4.10.
Lian, J.P. et al., "Bos1p, an Integral Membrane Protein of the Endoplasmic Reticulum to Golgi Transport Vesicles, Is Required for Their Fusion Competence", Cell 73: 735-745 (1993).
Rexach, M.F. et al., "Characteristics of Endoplasmic Reticulum-derived Transport Vesicles", J. Cell Biol., 126: 1133-1148 (1994).
Lian, J.P. et al., "Ypt1p implicated in v-SNARE activation", Nature, 372: 698-701 (1994).
S.o slashed.gaard, M. et al., "A Rab Protein Is Required for the Assembly of SNARE Complexes in the Docking of Transport Vesicles", Cell, 78: 937-948 (1994).
Hay, J.C. et al., "Mammalian Vesicle Trafficking Proteins of the Endoplasmic Reticulum and Golgi Apparatus", J. Biol. Chem., 271: 5671-5679 (1996).
Hay, J.C. et al., (Direct Submission), GenBank Sequence Database (Accession 1223898), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1223898).
Hay, J.C. et al., (Direct Submission), GenBank Sequence Database (Accession U42755), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1223897).
Adams et al., GenBank Record. Accession/Locus #T31927. Definition: Homo Sapiens CDNA 5' end similar to none.
Hiller et al., Gen Bank Record. Accession/Locus #R52442. Definition: Homo Sapiens CDNA Clone 39535 5'.

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