Chondroitinase compositions

Details Chondroitinase compositions Chondroitinase compositions

1998-05-01

1999-12-28

Weber, Jon P.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 9461, 435201, A61K 3846, A61K 3847, C12N 926

Patent

active

060078103

ABSTRACT:
This invention provides pharmaceutical compositions containing chondroitinase wherein a decrease in enzyme activity is very little even after long-term storage, and the pharmaceutical compositions are characterized in that they contain chondroitinase and a pharmaceutical carrier, and that an amount of reducing impurities per 1 g of said pharmaceutical carrier is 0.4 mL or less as a titer by a titration method with 0.01 N of ammonium ceric nitrate.

REFERENCES:
patent: 4696816 (1987-09-01), Brown
patent: 5496718 (1996-03-01), Hashimoto et al.
patent: 5716617 (1998-02-01), Khandke et al.
Kato, et al., Chemonucleolysis, No. 253, Apr. 1990, pp. 301-308.

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