Cholecystokinin antagonists, their preparation and therapeutic u

Details Cholecystokinin antagonists, their preparation and therapeutic u Cholecystokinin antagonists, their preparation and therapeutic u

1996-09-09

1998-12-08

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 546143, 546146, 546147, 548496, 530331, C07D20918, C07D21700, C07D20920, A61K 3800

Patent

active

058469427

ABSTRACT:
Novel cholecystokinin antagonists useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compounds of the invention are also useful in treating and/or preventing panic. Also disclosed are pharmaceutical compositions and methods of treatment using the antagonists as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.

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