Chiral cis-imidazolines

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S370000, C548S334100, C514S396000, C514S397000

Reexamination Certificate

active

07964724

ABSTRACT:
and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.

REFERENCES:
patent: 5457224 (1995-10-01), Ehrmann et al.
patent: 5925665 (1999-07-01), Payard et al.
patent: 6617346 (2003-09-01), Kong et al.
patent: 6734302 (2004-05-01), Kong et al.
patent: 363 061 (1990-04-01), None
patent: WO 00/78725 (2000-12-01), None
patent: 03/002509 (2003-01-01), None
patent: WO 03/051359 (2003-06-01), None
Hunter et al., Can. J. Chem., 50, pp. 669-677 (1972).
Wells et al., J. Org. Chem., 37, pp. 2158-2161 (1972).
Vassilev et al., Science, 303, pp. 844-848 (2004).
McCapra et al., Photochem. and Photobiol., 4, pp. 1111-1121 (1965).
Moormann, et al., Journal of Medicinal Chemistry, vol. 33, No. (2), pp. 614-626 (1990).
Japanese Office Action in related case JP 2007-517027 dated Jul. 8, 2010.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chiral cis-imidazolines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chiral cis-imidazolines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chiral cis-imidazolines will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2717731

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.