Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-11-16
1998-09-15
Teng, Sally P.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435697, 530350, 5303873, 530402, C12N 1562, C07K 1900
Patent
active
058080252
ABSTRACT:
Chimeric peptides or polypeptides that combine ligand binding portions from within the lectin and EGF domains of two different selectins are disclosed. The peptides or polypeptides can be constructed solely of the indicated portions of lectin or EGF domains or they can include portions of any of the remaining domains (SCR, transmembrane or cytoplasmic), or the entire extracellular portion, of a generic selectin molecule. The peptides or polypeptides also can be joined to a carrier protein (e.g., a soluble portion of an immunoglobulin molecule) to increase the serum half-life of the therapeutic agent. The chimeric polypeptides can be used as therapeutic agents to antagonize selectin function. They are also useful for screening for agents that are simultaneously antagonists of the function of lectin and EGF domains of different selectins.
REFERENCES:
patent: 4783330 (1988-11-01), Furie et al.
patent: 5026537 (1991-06-01), Daddona et al.
patent: 5081034 (1992-01-01), Bevilacqua et al.
patent: 5098833 (1992-03-01), Lasky et al.
patent: 5116964 (1992-05-01), Capon et al.
patent: 5216131 (1993-06-01), Lasky et al.
Aizawa et al., "Molecular basis of the recognition of intraveneously transplanted hemopoietic cells by bone marrow," Proc. Natl. Acad. Sci. USA 85:3180-3183 (1988).
Bargatze et al., "High Endothelial Venule Binding as a Predictor of the Dissemination of Passaged Murine Lymphomas," J. Exp. Med. 166:1125-1131 (1987).
Berg et al., "Homing Receptors and Vascular Addressins: Cell Adhesion Molecules that Direct Lymphocyte Traffic," Immunol. Rev. 108:421-427 (1989).
Bevilacqua et al., "Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins," Science 243:1160-1165 (1989).
Bevilacqua et al., "Identification of an inducible endothelial-leukocyte adhesion molecule," Proc. Natl. Acad. Sci. USA 84:9238-9242 (1987).
Bowen et al., "Characterization of a Human Homologue of the Murine Peripheral Lymph Node Homing Receptor," J. Cell Biol. 109:421-427 (1989).
Butcher et al., "Lymphocyte Adherence to High Endothelial Venules: Characterization of a Modified In Vitro Assay, and Examination of the Binding Syngenic and Allogenic Lymphocyte Populations," J. Immunol. 123:1996-2003 (1979).
Camerini et al., "Leu-8/TQ-1 is the human equivalent of the Mel-14 lymph node homing receptor," Nature 342:78-82 (1989).
Carbone et al., "Expression of Leu-8 Surface Antigen in B-Cell Lymphomas. Correlation with Other B-Cell Markers," J. Pathol. 154:133-140 (1988).
Chin et al., "Lymphocyte Recognition of Lymph Node High Endothelium. I. Inhibition of In Vitro Binding by a Component of Thoracic duct Lymph," J. Immunol. 125:1764-1769 (1980).
Chin et al., "Lymphocyte Recognition of Lymph Node High Endothelium. II. Characterization of an In Vitro Inhibitory Factor Isolated by Antibody Affinity Chromatography," J. Immunol. 125:1770-1774 (1980).
Chin et al. "Lymphocyte Recognition of Lymph Node High Endothelium, V. Isolation of Adhesion Molecules from Lysates of Rat Lymphocytes," J. Immunol. 131:1368-1374 (1983).
Collins et al., "Structure and Chromosomal Location of the Gene for Endothelial-Leukocyte Adhesion Molecule 1," J. biol. chem. 266:2466-2473 (1991).
Dana et al., "Two Functional Domains in the Phagocyte Membrane Glycoprotein Mo1 Identified with Monoclonal Antibodies," J. Immunol. 137:3259-3263 (1986).
DiStefano et al., "Identification of a truncated form of the nerve growth factor receptor," Proc. Natl. Acad. Sci. USA 85:270-274 (1988).
Dowbenko et al., "Characterization of the Murine Homing Receptor Gene Reveals Correspondence between Protein Domains and coding Exons," Genomics 9:270-277 (1991).
Downing et al., "Ligand and Protein Kinase C Downmodulate the Colony Stimulating Factor 1 Receptor by Independent Mechanisms," Mol. cell. Biol. 9:2890-2896 (1989).
Drickamer et al., "Complete amino acid sequence of a membrane receptor for glycoproteins," J. Biol. Chem. 256:5827-5839 (1981).
Drickamer et al., "Two Distinct Classes of Carbohydrate-recognition Domains in Animal Lectins," J. Biol. Chem. 263:9557-9560 (1988).
Duijvestijn et al., "Mechanisms and regulation of lymphocyte migration," Immunol. today 10:23-28 (1989).
Ezekowitz et al., "A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins," J. Exp. Med. 167:1034-1046 (1988).
Gallatin et al., "Lymphocyte Homing Receptors," Cell 44:673-680 (1986).
Gallatin et al., "A cell-surface molecule involved in organ-specific homing of lymphocytes," Nature 304:30-34 (1983).
Gatenby et al., "Dissection of Immunoregulatory Subpopulations of T Lymphocytes within the Helper and Suppressor Sublineages in Man," J. Immunol. 129;1997-2000 (1982).
Geng et al., "Rapid neutrophil adhesion to activated endothelium mediated by GMP-140," Nature 323:757-760 (1990).
Goldstein et al., "A Human Lymphocyte Homing Receptor, the Hermes Antigen, is Related to Catilage Proteoglycan Core and Link Proteins," Cell 56:1063-1072 (1989).
Gregory, "Isolation and structure of urogastrone and its relationship to epidermal growth factor," Nature 257:325-327 (1975).
Griffin et al., "Granulocyte-Macrophage Colony-Stimulating Factor and Other Cytokines Regulate Surface Expression of the Leukocyte Adhesion Molecule-1 on Human Neutrophils, Monocytes, and their Precursors," J. Immunol. 145:576-584 (1990).
Hallmann et al., "The peripheral lymph node homing receptor, LECAM-1, is involved in CD18-independent adhesion of human neutrophils to endothelium," Biochem. Biophys. Res. Comm. 174:236-243 (1991).
Harlow et al., "Antibodies: A Laboratory Manual," Cold Spring Harbor, pp. 72-154, (1988).
Harris et al., "Therapeutic Antibodies--the Coming of Age," Tibtech 11: 42-44 (1993).
Hidaka et al., "Isoquinolinessulfonamides, Novel and Potent Inhibitors of Cyclic Nucleotide Dependent Protein Kinase and Protein Kinace C," Biochemistry 23:5036-5041 (1984).
Hildreth et al., "The Human Lymphocyte Function-Associated (HFLA) Antigen and a Related Macrophage Differentiation Antigen HMac-1): Functional Effects of Subunit-Specific Monoclonal Antibodies," J. Immunol. 134:3272-3280 (1985).
Ichinose et al., "Amino-Acid Sequence of the b Subunit of Human Factor XII, a Protein Composed of Ten Repetitive Segments," Biochemistry 25:4633-4638 (1986).
Imai et al., "Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor," J. Cell Biol. 113:1213-1221 (1991).
Jalkanen et al., "Lymphocyte Recognition of High Endothelium: Antibodies to Distinct Epitopes of an 85-95-kD Glycoprotein Antigen Differentially Inhibit Lymphocyte Binding to Lymph Node, Mucosal, or Synovial Endothelial Cells," J. Cell Biol. 105:983-990 (1987).
Johnson, G.J., et al., "Thromboxane unresponsive dog platelets have an abnormal thromboxane A.sub.2 /prostaglandin H.sub.2 receptor-linked G protein," Blood Suppl. 72:327A (1988).
Johnston, G.I., et al., "Cloning of GMP-140, a Granule Membrane Protein of Platelets and Endothelium: Sequence Similarity to Proteins Involved in Cell Adhesion and Inflammation," Cell 56:1033-1044 (1989).
Johnston, G.I., et al., "Structure of the Human Gene Encoding Granule Membrane Protein-140, a Member of the Selectin Family of Adhesion Receptors for Leukocytes," J. Biol. Chem. 265:21381-21385 (1990).
Jung et al., "Rapid Modulation of Homing Receptors (gp90.sup.MEL-14) induced by Activators of Protein Kinase C," J. Immunol. 144:130-136 (1990).
Jutila et al., "Characterization of a Functionally Important and Evolutionarily Well-Conserved Epitope Mapped to the Short Consensus Repeats of E-Selectin and L-Selectin," J. Exp. Med. 175:1565-1573 (1992).
Jutila et al., "Function and Regulation of the Neutrophil MED-14 Antigen In Vivo: Comparison with LFA-1 and MAC-1," J. Immunol. 143:3318-3324 (1989).
Kanof et al., "Leu-8 Antigen Expression is Diminished During Cell Activation But Does Not Correlate With Effector Function of Activated Lymphocytes," J. Immunol. 140:3701-3706 (1988).
Kansas et al., "Molecular Mapping of Functional Domains of the Leukocyte Receptor for Endothelium, LAM-1,
Kansas Geoffrey S.
Tedder Thomas F.
Dana-Farber Cancer Institute Inc.
Gunnison Jane T.
Haley, Jr. James F.
Teng Sally P.
LandOfFree
Chimeric selectins as simultaneous blocking agents for component does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chimeric selectins as simultaneous blocking agents for component, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric selectins as simultaneous blocking agents for component will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-88979