Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Reexamination Certificate
2006-05-16
2006-05-16
Saucier, Sandra E. (Department: 1651)
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
Reexamination Certificate
active
07045341
ABSTRACT:
A chemoenzymatic process for the stereoselective preparation of both the (R) and (S) enantiomers of 3-hydroxy-3-(2-thienyl) propanenitrile has been developed. These optically pure key intermediates were prepared by enzymatic resolution of (±)3-hydroxy-3-(2-thienyl) propanenitrile both by transesterification and by hydrolysis reaction which were then transformed to both enantiomers of duloxetine.
REFERENCES:
patent: 02/057475 (2002-07-01), None
patent: 2004/013123 (2004-02-01), None
Gollapalli Bhasker Ramesh Khanna
Kamal Ahmed
Maddamsetty Venkateswara Rao
Rondla Ramu
Council of Scientific and Industrial Research
Ladas & Parry LLP
Saucier Sandra E.
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