Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2006-05-16
2008-10-28
Hartley, Michael G. (Department: 1618)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S422000, C424S489000, C424S496000, C424S497000, C424S501000, C424S502000
Reexamination Certificate
active
07442385
ABSTRACT:
A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
REFERENCES:
patent: 4978713 (1990-12-01), Goldenberg
patent: 5508317 (1996-04-01), Muller
patent: 5583163 (1996-12-01), Muller
patent: 5782974 (1998-07-01), Sorensen et al.
patent: 0 240 424 (1991-05-01), None
patent: 06-3295642 (1994-11-01), None
patent: WO 95/13798 (1995-05-01), None
patent: WO 97/45131 (1997-12-01), None
patent: WO 99/12577 (1999-03-01), None
patent: WO 01/68720 (2001-09-01), None
Ball et al., “In Vitro Stability of Tris-acryl Gelatin Microspheres in a Multipharmaceutical Chemoembolization Solution,”J. Vasc. Interv. Radiol., vol. 14, No. 1, (2003), pp. 83-88.
Juni et al., “Preparation and Evaluation in Vitro and in Vivo of Polylactic Acid Microspheres Containing Doxorubicin,”Chem. Parm. Bull., vol. 33, No. 1, (1985), pp. 313-318.
Jones et al., “Enhanced in vivo activity of adriamycin incorporated into controlled release microspheres,”Br. J. Cancer, vol. 59, (1989), pp. 743-745.
Wingard et al., “Cell Surface Effects of Adriamycin and Carminomycin Immobilized on Cross-Linked Polyvinyl Alcohol,”Cancer Research, vol. 45, (Aug. 1985), pp. 3529-3536.
Benoit et al., “Microcapsules and Microspheres for Embolization and Chemoembolization,”Polymeric Nanoparicles and Microspheres, and Guiot, et al., CRC Press, Boca Raton, Fl, (1986), pp. 137-174.
Longo et al., “Preparation and Drug Release Properties of Albumin-Polyglutamic Acid-Adriamycin Microspheres,”Polymer Preprints, (1985), vol. 24, pp. 56-57.
Sawaya et al., “Binding Mechanism of Doxorubicin in Ion-Exchange Albumin Microcapsules,”J. Pharm. Sic., (1987), vol. 76, No. 6, pp. 475-480.
Codde et al., “Reduced Toxicity of Adriamycin by Incorporation into Ion Exchange Microspheres: A Therapeutic Study Using a Rat Liver Tumour Model,”Anticancer Research, (1990), vol. 10, No. 6, pp. 1715-1718.
Vora et al., “Investigation of the Relative Affinity of Doxorubicin for Neural and Negatively Charged Particulate Carriers,”Drug Development and Industrial Pharmacy, vol. 19, No. 7, (1993), pp. 759-771.
Fajardo Gonzalez Maria Victoria
Garcia Pedro
Hall Brenda
Leppard Simon
Lewis Andrew Lennard
Biocompatibles UK Limited
Hartley Michael G.
Sughrue & Mion, PLLC
Young Micah-Paul
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