Chemically modified biological molecules and methods for...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S402000, C436S518000

Reexamination Certificate

active

06858713

ABSTRACT:
The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid supports, for instance, a glass surface, without first derivatizing the glass surface. High-density microarrays based on these modified molecules as well as methods for preparing these microarrays are also useful.

REFERENCES:
patent: 4231910 (1980-11-01), Plueddemann
patent: 4637687 (1987-01-01), Haim et al.
patent: 4713116 (1987-12-01), Krinski et al.
patent: 4806631 (1989-02-01), Carrico et al.
patent: 4818681 (1989-04-01), Dattagupta
patent: 4826789 (1989-05-01), Jones et al.
patent: 4826790 (1989-05-01), Jones et al.
patent: 4937188 (1990-06-01), Giese et al.
patent: 4957858 (1990-09-01), Chu et al.
patent: 4963436 (1990-10-01), Jones et al.
patent: 5008220 (1991-04-01), Brown et al.
patent: 5024933 (1991-06-01), Yang et al.
patent: 5055429 (1991-10-01), James et al.
patent: 5190864 (1993-03-01), Giese et al.
patent: 5215882 (1993-06-01), Bahl et al.
patent: 5401415 (1995-03-01), Rauh et al.
patent: 5514785 (1996-05-01), Van Ness et al.
patent: 5554744 (1996-09-01), Bhongle et al.
patent: 5601982 (1997-02-01), Sargent et al.
patent: 5610287 (1997-03-01), Nikiforov et al.
patent: 5630932 (1997-05-01), Lindsay et al.
patent: 5641630 (1997-06-01), Snitman et al.
patent: 5851769 (1998-12-01), Gray et al.
patent: 6048695 (2000-04-01), Bradley et al.
patent: 6426183 (2002-07-01), Beattie
patent: WO 9957323 (1999-11-01), None
Kumar, et al.,Silanized nucleic acids: a general platform for DNA immobilization, Nucleic Acids Res. (200), vol. 28, No. 14, E71, II-VI, XP002188992.
Li, Minqian, et al.,Methods for manufacturing DNA chips with large immobilized DNA fragmentsShanghai Inst. Of Atomic Nucleus, Chinese Academy of Sciences, Peop. R) Jan. 26, 200, XP002189763.
Beattie, W., et al.,Hybridization of DNA Targets to Glass-Tethered Oligonucleotide Probes, Molecular Biotechnology 4:213-25 (1995).
Castellino, A.,When the Chips and Down,Genome Research 7:943-6(1997).
DeRisi, J., et al.,Use of a cDNA Microarray to Analyse Gene Expression Patterns in Human Cancer, Nature Genetics 14:457-60 (1996).
Guo, Z., et al.,Direct Fluorescence Analysis of Genetic Polymorphisms by Hybridization with Oligonucleotide Arrays on Glass Supports, Nucleic Acids Research 22:5456-65 (1994).
Hacia, J., et al.,Detection of Heterozygous Mutations in BRCA1 Using High Density Oligonucleotide Arrays and Two-Colour Fluorescence Analysis, Nature Genetics 14:441-7 (1996).
Lockhart, D., et al.,Expression Monitoring by Hybridization to High-Denisty Oligonucleotide Arrays, Nature Biotechnology 14:1675-80 (1996).
Marshall, A.,DNA Chips: An Array of Possibilities, Nature Biotechnology 16:27-31 (1998).
Maskos, U., E. Southern, Oligonucleatide Hybridisations on Glass supports, Nucleic Acids Research 20:1679-84 (1992).
Ramsay. G.,DNA Chips: State-of-the-Art, Nature Biotechnology 16:40-44 (1998).
Schena, M.Genome Analysis with Gene Expression Microarrays, BioEssays 18:427-31 (1996).
Schena, M., et al.,Quantitative Monitoring of Gene Expression Patterns with a Complimentary DNA Microarray, Science 270:467-70 (1995).
Schena, M., et al.,Parallel Human Genome Analysis: Microarrays-based Expression Monitoring of 1000 Genes,Proc. Natl. Acad. Sci. USA 93:10614-9 (1996).
Shalon, D., et al.,A DNA Microarray System for Analyzing Complex DNA Samples Using Two-color Fluorescent Probe Hybridization,Genome Research 6:639-45 (1996).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chemically modified biological molecules and methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemically modified biological molecules and methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemically modified biological molecules and methods for... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3507898

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.