Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-05-23
1997-09-09
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 231, 536 243, 536 2433, C12Q 168, C12P 1934, C07H 2102, C07H 2104
Patent
active
056655487
ABSTRACT:
DNA sequences and corresponding amino acid sequences from the HLA class II beta region of the human genome that are associated with insulin-dependent diabetes mellitus (IDDM) and Pemphigus vulgaris (PV) have been identified. Specifically, marker DNA sequences which detect either directly or indirectly the identity of the codon encoding for the amino acid at position 57 of the DQ.beta. protein sequence are disclosed as well as sequences from the DR.beta. region. These sequences may be used to generate DNA hybridization probes and antibodies for assays to detect a person's susceptibility to autoimmune diseases, such as IDDM and PV. Such antibodies and peptides encoded by said DNA sequences can be used therapeutically or prophylactically.
REFERENCES:
patent: 4582788 (1986-04-01), Erlich
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4965189 (1990-10-01), Owerbach
patent: 4971902 (1990-11-01), Nepom
patent: 5039606 (1991-08-01), Nepom
patent: 5059519 (1991-10-01), Owerbach
patent: 5110920 (1992-05-01), Erlich
Brautbar et al., 1980, "HLA-DRw4 in Pemphigus Vulgaris Patients in Israel" Tissue Antigens 16:238-243.
Ryder et al., 1981, "Gentics of HLA Disease Association" Ann. Rev. Genet. 15:169-187.
Svejgaard et al., 1983, "HLA and Disease 1982--A Survey" Immunol. Rev. 70:193-218.
Doniach et al., 1983, "Etiology of Type I Diabetes Mellitus: Heterogeneity and Immunological Events Leading to Clinical Onset" Ann. Rev. Med. 34:13-20.
Todd et al. Nature 329:599-604 1987.
Angellini et al. PNAS 83:4489-4493 1987.
Szafer et al. PNAS 84: 6542-6545 1987.
Owerbach et al. Immunogenetics 24: 41-46 1986.
Gregerson et al. PNAS 83: 2642-2646 1986.
Conner et al., Jan., 1983, "Detection of Sickle Cell Beta-S-Globin Allele by Hybridization With Synthetic Oligonucleotides" Proc. Natl. Acad. Sci. USA 80:278-282.
Long et al., 1983, "Complete Sequence of an HLA-DR beta Chain Deduced from a cDNA Clone and Idenfication of Multiple Non-Allelic DR beta Chain Genes" EMBO J. 2(3):389-394.
Owerbach et al., 1983, "HLA-D Region B Chain DNA Endonuclease Fragments Differ Between HLA-DR Identical Healthy and Insulin-Dependent Diabetic Individuals" Nature 303:815-817.
Erlich et al, 1984, "HLA Class II DNA Polymorphisms: Markers for Genetic Predisposition to Insulin-Dependent Diabetes" Banbury Reports 16:321-331.
Gorski et al., 1984, "Molecular Organization of the HLA-SB Region of the Human Major Histocompatibility Complex and Evidence for Two SB Beta-Chain Genes" Proc. Natl. Acad. Sci. USA 81:3934-3938.
Owerbach et al., Oct., 1984, "Susceptibility to Insulin-Dependent Diabetes Defined by Restriction Enzyme Polymorphism of HLA-D Region Genomic DNA" Diabetes 33:958-965.
Kagnoff et al., Nov., 1984, "Possible Role for a Human Adenovirus in the Pathogenesis of Celiac Disease" J. Exp. Med. 160:1544-1557.
Giles et al., 1985, "Structure, Function, and Genetics of Human Class II Molecules" Adv. Immunol. 37:1-71.
Silver et al., 1985, "la Epitopes and Their Relationship to Disease Susceptibility Genes" Disease Markers 3:155-168.
Trowsdale et al., 1985, "Structure, Sequence and Polymorphism in the HLA-D Region" Immunological Reviews 85:4-43.
Cohen-Haguenauer et al., May, 1985, "A Systematic Study of HLA Class II-Beta DNA Restriction Fragments in Insulin-Dependent Diabetes Mellitus" Proc. Natl. Acad. Sci. USA 82:3335-3339.
Raffel and Rotter, May/Jun., 1985, "The Genetics of Diabetes" Clinical Diabetes 3:50-54.
Yoon and Ray, Sep.-Oct., 1985, "Perspectives on the Role of Viruses in Insulin-Dependent Diabetes" Diabetes Care 8(Supp. 1):39-44.
Arnheim et al., Oct., 1985, "Use of Pooled DNA Samples to Detect Linkage Disequilibrium of Polymorphic Restriction Fragments and Human Disease: Studies of the HLA Class II Loci" Proc. Natl. Acad. Sci. USA 82:6970-6974.
Stetler et al., Dec., 1985, "Polymorphic Restriction Endonuclease Sites Linked to the HLA-DR alpha Gene: Localization and Use as Genetic Markers of Insulin-Dependent Diabetes" Proc. Natl. Acad. Sci. USA 82:8100-8104.
Kim et al., Dec., 1985, "Identification of a Polymorphic Variant Associated With HLA-DQw3 and Characterized by Specific Restriction Sites Within the DQ B-Chain Gene" Proc. Natl. Acad. Sci. USA 82:8139-8143.
Gregersen et al., Apr., 1986, "Molecular Diversity of HLA-DR4 Haplotypes" Proc. Natl. Acad. Sci. USA 83:2642-2646.
Tait et al., 1986, "DR4 and Susceptibility to Type I Diabetes Mellitus: Discrimination of High Risk and Low Risk DR4 Haplotypes on the Basis or TA10 Typing" Tissue Antigens 28:65-71.
Oldstone et al., 1986, Concepts in Viral Pathogenesis II (ed. Notkins et al.) pp. 195-202, Chapter 23 entitled "Molecular Mimicry".
Owerbach et al., 1986, "Characterization of Three HLA-DR Beta Genes Isolated From an HLA-DR 3/4 Insulin-Dependent Diabetic Patient" Immunogenetics 24:41-46.
Holbeck and Nepom, 1986, "Exon-Specific Oligonucleotide Probes Localize HLA-DQ Beta Allelic Polymorphisms" Immunogenetics 24:251-258.
Srinivasappa et al., Jan., 1986, "Molecular Mimicry: Frequency of Reactivity of Monoclonal Antiviral Antibodies with Normal Tissues" J. Virology 57(1):396-401.
Roudier et al., Nov. 5-7, 1987, Am. Rheumatism Assn. Abstract.
Eisenbarth, May 22, 1986, "Type I Diabetes Mellitus A Chronic Autoimmune Disease" N. Eng. J. Med. 314(21):1360-1368.
Angelini et al., Jun., 1986, "High-Resolution Analysis of the Human HLA-DR Polymorphism by Hybridization With Sequence-Specific Oligonucleotide Probes" Proc. Natl. Acad. Sci. USA 83:4489-4493.
Gorski et al., Jul. 3, 1986, "Polymorphism of Human Ia Antigens: Gene Conversion Between Two DR beta Loci Results in a New HLA-D/DR Specificity" Nature 322:67-70.
Scharf et al., Sep. 5, 1996, "Direct Cloning and Sequence Analysis of Enzymatically Amplified Genomic Sequences" Science 233:1076-1078.
Sheldon et al., Dec., 1986, "Use of Nonisotopic M13 Probes for Genetic Analysis: Application to HLA Class II Loci" Proc. Natl. Acad. Sci. USA 83:9085-9089.
Bodansky et al., Dec. 13, 1986, "Islet-Cell Antibodies and Insulin Autoantibodies in Association with Common Viral Infections" Lancet pp. 1351-1353.
Nakhasi et al., Dec. 15, 1986, "Sequence and Expression of E Envelope Protein" 261(35):16616-16621.
Henson et al., 1987, "Polymorphisms of DQ beta Genes in HLA-DR4 Haplotypes from Healthy and Diabetic Individuals" Immunogenetics 25:152-160.
McChesney et al., 1987, "Viruses Perturb Lymphocyte Functions: Selected Principles Characterizing Virus-Induced Immunosuppression" Ann. Rev. Immunol. 5:279-304.
Erlich et al., 1987, "The Molecular Analysis of HLA Class II Gene Polymorphism" Perspectives in Immunogenetics and Histocompatibility 7:93-111.
Michelson and Lernmark, Apr., 1987, "Molecular Cloning of a Polymorphic DNA Endonuclease Fragment Associates Insulin-Dependent Diabetes Mellitus With HLA-DQ" J. Clin. Invest. 79:1144-1152.
Acha-Orbea and McDevitt, Apr. 1987, "The First External Domain of the Nonobese Diabetic Mouse Class II I-A Beta Chain is Unique" Proc. Natl. Acad. Sci. USA 84:2435-2439.
Schwimmback et al., Jul., 1987, "Autoantibodies to HLA B27 in the Sera of HLA B27 Patients With Ankylosing Spondylitis and Reiter's Syndrome" J. Exp. Med. 166:173-181.
Sette et al., Jul. 30, 1987, "Structural Characterizations of an Antigen Required for its Interaction with Ia and Recognition by T Cells" Nature 328:395-399.
Szafer et al., Sep., 1987, "Detection of Disease-Specific Restriction Fragment Length Polymorphisms in Pemphigus Vulgaris Linked to the DQw1 and DQw3 Alleles of the HLA-D Region" Proc. Natl. Acad. Sci. USA 84:6542-6545.
Oldstone, Sep. 11, 1987, "Molecular Mimicry and Autoimmune Disease" Cell 50:819-820.
Niven et al., Oct. 3, 1987, "Susceptibility to Coeliac Disease Involves Genes in HLA-DP Region" Lancet p. 805.
Todd et al., Oct., 1987, "HLA-DQ Beta Gene Contributes to Susceptibility and Resistance to Insulin-Dependent Diabetes Mellitus" Nature 329:599-604.
Marx, Oct. 30, 1987, "Structure of MHC Protein Solved" Science 238:613-614.
Erlich Henry A.
Horn Glenn T.
Johnston George W.
Jones W. Gary
Petry Douglas A.
Rees Dianne
Roche Molecular Systems Inc.
LandOfFree
Characterization and detection of sequences associated with auto does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Characterization and detection of sequences associated with auto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Characterization and detection of sequences associated with auto will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-68757