Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

1974-11-14

1977-02-08

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260307H, 2603457, 260349, 2604654, 260481R, 260526S, 260544Y, 424246, C07D50150, C07D50156

Patent

active

040071774

ABSTRACT:
A compound of the formula ##STR1## wherein A represents acetoxy group, carbamoyloxy group or (1-metyl-1H-tetrazol-5-yl)thio group and Y represents propargylthio group, azidomethylthio group, 2-hydroxyethylthio group, 3-isoxazolyloxy group, 3-isoxazolylthio group, methylsulfonyl group, ethylsulfonyl group, 2-cyanoethyl-sulfonyl group or sydnon-3-yl group and nontoxic pharmaceutically acceptable salts thereof are prepared by a process which comprises reacting a compound of the formula ##STR2## wherein R represents a protective group for a carboxyl group and A has the same meaning as defined above with a carboxylic acid of the formula

REFERENCES:
patent: 3530123 (1970-09-01), Takano et al.
patent: 3840531 (1974-10-01), Greene et al.
patent: 3883520 (1975-05-01), De Marinis
patent: 3887549 (1975-06-01), Christensen
patent: 3905963 (1975-09-01), Webber
patent: 3920639 (1975-11-01), Dolfini
Cama et al., J. Am. Chem. Soc., v. 94(4) pp. 1408-1410 (1972).

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