Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-10-11
2000-07-11
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514206, 540226, 540227, A61K 31545, C07D50159, C07D50124
Patent
active
060873558
ABSTRACT:
The present invention includes novel compounds of formula ##STR1## where A, B, D, and E are selected from the group consisting of carbon, nitrogen and sulfur, R.sup.99 is selected from the group consisting of sulfur, SO, SO.sub.2, NH, N-alkyl, oxygen, C.dbd.C (cis or trans), and C.tbd.C, and R.sup.12 is NR.sup.13 R.sup.14, ##STR2## The invention also includes the pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistant to .beta.-lactam antibiotics and are useful as antibacterial agents. The invention also relates to novel intermediates useful for making the novel compounds of the present invention and to novel methods for producing the novel compounds and intermediate compounds.
REFERENCES:
patent: 3992377 (1976-11-01), Chauvette et al.
patent: 4256739 (1981-03-01), Woodward et al.
patent: 4307116 (1981-12-01), Farge et al.
patent: 4307230 (1981-12-01), Farge et al.
patent: 4584290 (1986-04-01), Takaya et al.
patent: 4870168 (1989-09-01), Baker et al.
patent: 5025006 (1991-06-01), Dinninno et al.
patent: 5077287 (1991-12-01), Temansky
Ege, "Organic Chemistry" (Heath) & Co) p. 98, 1984.
Bruice, "Organic Chemistry, 2nd Ed" (Prentice Hall) pp. 53,63,1083, 1998.
Barrett, "Amide Transacylation in Penicillin and Cephalosporin Derivatives," J.C.S. Perkin I pp. 1629-1633 (1979).
Chauvette et al., "Chemistry of Cephalosporin Antibiotics. XXI. Conversion of Penicillin to Cephalexin," J. Org. Chem. 36:1259-1267 (1971).
Farina et al., "A General Route to 3-Functionalized 3-Norcephalosporins," J. Org. Chem. 54:4962-4966 (1989).
Greene et al., Protective Groups in Organic Synthesis, John Wiley & Sons, New York, pp. 309-315 (1991).
Georg, The Organic Chemistry of .beta.-Lactams, VCH (1992) (Table of Contents Only).
Kondo et al., "New 2"-Amino Derivatives of Arbekacin, Potent Aminoglycoside Antibiotics Against Methicillin-Resistant Staphylococcus aureus, J. Antibiotics 46:531-534 (1993).
Larock, "8. Lactone and Lactam Formation," Comprehensive Organic Transformations, VCH Publishers, pp. 941-962 (1992).
NCCLS publication entitled Methods for Dilution Antimicrobial Susceptibility Tests for Bacterial That Grow Aerobically--Third Edition; Approved Standard, NCCLS 13(25) (1993).
Ohki et al., "FK037. A New Parenteral Cephalosporin With a Broad Antibacterial Spectrum: Synthesis and Antibacterial Activity," J. Antibiotics 46:359-361 (1993).
Sanders and Sanders, "Microbiological Characterization of Everninomicins B and D," Antimicrobial Agents and Chemotherapy 6:232-238 (1974).
Sprangler et al., "Susceptibilities of Penicillin-Susceptible and-Resistant Strains of Streptococcus pneumoniae to RP 59500, Vancomycin, Erythromycin, PD 131628, Sparfloxacin, Temafloxacin, Win 57273, Ofloxacin, and Ciprofloxacin," Antimicrobial Agents and Chemotherapy 36:856-859 (1992).
Sum et al., "Glycyclyclnes. 1. A New Generation of Potent Antibacterial Agents through Modification of 9-Aminotetracyclines," J. Med. Chem. 37:184-188 (1994).
Ternansky et al., "Discovery and Structure-Activity Relationship of a Series of 1-Carba-1-dethiacephems Exhibiting Activity against Methicillin-Resistant Staphylococcus aureus," J. Med. Chem. 36:1971-1976 (1971).
Cho In-Seop
Glinka Tomasz W.
Hecker Scott J.
Lee Ving J.
Zhang Zhijia J.
Berch Mark L.
Microcide Pharmaceuticals, Inc.
LandOfFree
Cephalosporin antibiotics does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cephalosporin antibiotics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cephalosporin antibiotics will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-542615