Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-03-23
1997-07-22
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 231, 536 243, C12Q 168, C12P 1934, C07H 2102, C07H 2104
Patent
active
056502800
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a novel cellubrevin (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cb, expression vectors for the production of purified CB, antibodies capable of binding specifically to CB, hybridization probes or oligonucleotides for the detecting the upregulation of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CB, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CB.
REFERENCES:
Harvey T. McMahon et al., "Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein," Nature 364-346-349 (1993).
Naveen Arora, "Cytotoxic Effects of a Chimeric Protein Consisting of Tetanus Toxin Light Chain and Anthrax Toxin Lethal Factor in Non-neuronal Cells," J Biol Chem 269:26165-26171 (1994).
I. Christina Bark et al., "Regulated vesicular fusion in neurons: Snapping together the details," Proc Natl Acad Sci USA 91:4621-4624 (1994).
Egenhard Link et al., "Cleavage of Cellubrevin by Tetanus Toxin Does Not Affect Fusion of Early Endosomes", J Biol Chem 268:18423-18426 (1993).
Evelyn Ralston et al., "Expression of the Synaptic Vesicle Proteins VAMPs/Synaptobrevins 1 and 2 in Non-neural Tissues," J Biol Chem 269:15403-15406 (1994).
Hawkins Phillip R.
Seilhamer Jeffrey J.
Stuart Susan G.
Incyte Pharmaceuticals Inc.
Jones W. Gary
Luther Barbara J.
Rees Dianne
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