Cell surface antigens of human astrocytoma

Details Cell surface antigens of human astrocytoma Cell surface antigens of human astrocytoma

1982-09-01

1987-02-10

Warren, Charles F.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

436548, 435 68, 4351722, 435948, 935104, 935110, C12N 500, C12N 1500, C12P 2100, C12R 191

Patent

active

046422919

ABSTRACT:
Method of forming an antibody producing hybridoma cell line by fusing a myeloma cell line with splenocytes derived from BALB/c mice immunized with human astrocytoma tumor cells, the hybridoma cell line formed, and the monoclonal antibodies generated by said hybridoma cell line. A method of phenotyping astrocytoma tumor cells comprising determining the reaction of said cells to various monoclonal antibodies to astrocytoma tumor cells is also provided.

REFERENCES:
Schnegg et al, "Human Glioma-Associated Antigens Detected by Monoclonal Antibodies", Cancer Research, 41, pp. 1209-1213 (3-1981).
Herlyn et al, "Specific Immunoreactivity of Hybridoma-Secreted Monoclonal Anti-Melanoma Antibodies to Cultured Cells and Freshly . . . ", Cancer Research, 40, pp. 3602-3609 (1980).
Liao et al, "Common Neuroectodermal Antigens on Human Melanoma, Neuroblastoma, Retinoblastoma, Glioblastoma and Fetal Brain . . . ", European Journal of Immunology, 11, pp. 450-454 (6-1981).
Wikstrand et al, "Expression of Fetal Brain Antigens by Human Tumors of Neuroectodermal Origin as Defined by Monoclonal Antibody", Cancer Research, 42, pp. 267-275 (1-1982).
Carrel et al, "Expression of Neuroectodermal Antigens Common to Melanomas, Gliomas and Neuroblastomas", Acta Neuropathology, 57(2-3), pp. 158-164 (1982).
Wikstrand et al, "Human Fetal Brain Antigen Expression Common to Tumors of Neuroectodermal Tissue Origin", Journal of Neuroimmunology, 3(1), pp. 43-62 (8-1982).
Pfreundschuh et al, "Serological Analysis of Cell Surface Antigens of Malignant Human Brain Tumors", Proceedings of the National Academy of Sciences, 75(10), pp. 5122-5126, (1978).
Dippold et al, "Cell Surface Antigens of Human Malignant Melanoma: Definition of Six Antigenic Systems with Mouse Monoclonal Antibody", Proceedings of the National Academy of Sciences, 77(10), pp. 6114-6118 (1980).
Knowles et al, "Isolation and Characterization of Plasma Membranes from Transplantable Human Astrocytoma, Oat Cell Carcinoma . . . ", Cancer Research, 41, pp. 4131-4136 (1981).
Pukel et al, "GD3 A Prominent Ganglioside of Human Melanoma", Journal of Experimental Medicine, 155 (4), pp. 1133-1147 (4-1982).

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