Cell co-culture apparatus for researching cell interaction...

Chemistry: molecular biology and microbiology – Apparatus – Bioreactor

Reexamination Certificate

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Details

C435S294100, C435S288300, C435S288400, C435S288500, C435S305200

Reexamination Certificate

active

07968331

ABSTRACT:
A cell co-culture apparatus and a method of co-culturing and isolating cells using the cell co-culture apparatus to research interactions between cells by direct contact between the cells are provided. The cell co-culture apparatus includes a first substrate including a substrate portion and a plurality of projections provided on a surface of the substrate portion, each of the projections having a top surface for culturing cells, a second substrate including a same number of first channels as a number of the projections such that the channels fit with the projections and substrate surfaces formed between the first channels, and a third substrate including a plurality of second channels corresponding with the top surfaces and a plurality of third channels corresponding with the substrate surfaces.

REFERENCES:
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patent: 2002/0173033 (2002-11-01), Hammerick et al.
patent: 2004/0053403 (2004-03-01), Jedrzejewski et al.
patent: 2004/0214313 (2004-10-01), Zhang et al.
patent: 2005/0208471 (2005-09-01), Elias
patent: 2005123950 (2005-12-01), None
A.M.P. Turner, et al. “Attachment of astroglial cells to microfabricated pillar arrays of different geometries”, Pub Jun. 28, 2000, Journal of Biomedical Materials Research Part A, vol. 51, Issue 3, pp. 430-441.
Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells; Quin Shen, Susan K. Goderie, Li Jin, Nithin Karanth, Yu Sun, Natalia Abramova, Peter Vincent, Kevin Pumiglia, Sally Temple; May 28, 2004, vol. 304; SCIENCE; pp. 1338-1340.
European Search Report; EP06127331; Aug. 1, 2007 All references cited in the Search Report and not previously submitted are listed above.

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