CD95 regulatory gene sequences

Details CD95 regulatory gene sequences CD95 regulatory gene sequences

1996-08-30

1999-06-15

McKelvey, Terry

Chemistry: molecular biology and microbiology

Vector, per se

536 231, 536 235, 536 241, C12N 1563, C12N 1511, C12N 1512

Patent

active

059121688

ABSTRACT:
Regulatory DNA sequences that silence and enhance transcription of coding portions of the CD95 gene, which is instrumental in apoptosis, are disclosed. Proteinaceous transcription factors that bind to the silencer and enhancer regulatory sequences are also disclosed and are useful for modulating the expression of CD95 or other proteins. Methods for regulating apoptosis have therapeutic and prophylactic applications for a variety of disorders, including cancer, viral and retroviral infections, neurodegenerative disorders, immune system dysfunction, and other disorders.

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