Cathepsin S inhibitors

Details Cathepsin S inhibitors Cathepsin S inhibitors

2005-05-31

2008-12-16

Shiao, Rei-Tsang (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S317000, C546S208000

Reexamination Certificate

active

07465745

ABSTRACT:
This invention relates to peptidyl compounds of the formulas (I) and (II) active as cathepsin S, a cysteine protease, inhibitors. The compounds are selective, reversible inhibitors of the cathepsin S are therefore useful in the treatment of autoimmune and other diseases. The invention also relates to processes for preparing such compounds and pharmaceutical compositions comprising them.

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Trojanowski, John Q., “Alzheimer's Disease, Parkinson's Disease and Related Brain Disorders: Brief Overview for Patients and Caregivers” internet article, posted Oct. 1999, http://www.uphs.edu.

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