Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2003-04-30
2009-08-04
Burkhart, Michael (Department: 1633)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S320100, C435S325000, C435S006120, C424S093100, C800S003000
Reexamination Certificate
active
07569681
ABSTRACT:
The present invention relates to a new family of structurally and functionally related nucleic acids and proteins, designed the CATERPILLER family, which is characterized by landmark structural motifs including a nucleotide binding domain and leucine-rich repeat domains.
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Accession No. NT—009325;Homo sapienschromosome 11 genomic contig; Source:Homo sapiens(2003).
Accession No. NT—009334;Homo sapienschromosome 11 working draft sequence segment; Source:Homo sapiens(Aug. 23, 2001).
Accession No. NT—015360;Homo sapienschromosome 16 working draft sequence segment; Source:Homo sapiens(Feb. 6, 2002).
Accession No. NT—024766;Homo sapienschromosome 16 working draft sequence segment; Source:Homo sapiens(Feb. 6, 2002).
Aganna, et al. 2002. Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity , sensorineural deafness, and AA amyloidosis.Arthritis Rheum46:2445.
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Banerjee, et al. 2001. The leucine-rich repeat domain can determine effective interaction between RPS2 and other host factors in arabidopsis RPS2-mediated disease resistance.Genetics158:439.
Bertin and DiStefano. 2000. The PYRIN domain: a novel motif found in apoptosis and inflammation proteins.Cell Death Differ. 7:1273.
Buchanan and Gay. 1996. Structural and functional diversity in the leucine-rich repeat of proteins.Prog Biophys Mol Biol. 65:1.
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Dodds, et al. 2001. Six Amino Acid Changes Confined to the Leucine-Rich Repeat beta-Strand/beta-Turn Motif Determine the Difference between the P and P2 Rust Resistance Specificities in Flax.Plant Cell13:163.
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Database entry ofHomo sapienscryopyrin (CIAS1) mRNA, complete cds, alternatively spliced, Accession No. AF410477.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=17026371> (2006).
Database entry ofHomo sapiensPYRIN-containing APAF1-like protein 1 (PYPAF1) mRNA, complete cds, Accession No. AF420469.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=18182338> (2006).
Database entry ofHomo sapiensNALP3 long isoform (NALP3) mRNA, complete cds, Accession No. AF468522.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=18699562> (2006).
Database entry ofHomo sapienscryopyrin (CIAS1) mRNA, complete cds, alternatively spliced, Accession No. AF427617.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=17026377> (2006).
Database entry ofHomo sapiensNALP3 short isoform mRNA, complete cds, Accession No. AF418985.2 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=19718650> (2006).
Database entry ofHomo sapienscDNA: FLJ23541 fis, clone LNG08276, highly similar to AF054176Homosapiensangiotensin/vasopressin receptor Aii/AVP mRNA, Accession No. AK027194.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=10440263> (2006).
Database entry ofHomo sapienschromosome 1 clone RP11-433K2, complete sequence, Accession No. AC104335.2 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=22024575> (2006).
Database entry of cold autoinflammatory syndrome 1 [Homo sapiens], Accession No. CAI17153.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=55961964> (2006).
Database entry of PYRIN-containing APAF1-like protein 1 [Homo sapiens], Accession No. AAL65136.1 < www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=18182339> (2006).
Database entry of NALP3 long isoform [Homo sapiens], Accession No. AAL78632.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=18699563> (2006.
Database entry of cold autoinflammatory syndrome 1 [Homo sapiens], Accession No. CAI17154.1 < www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=55961965> (2006).
Database entry of cryopyrin [Homo sapiens], Accession No. AAL12498.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=17927238> (2006).
Database entry of NALP3 intermediate isoform [Homo sapiens], Accession No. AAM14669.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=20268804> (2006).
Database entry ofHomo sapiensPYRIN-containing APAF1-like protein 7 mRNA, complete cds, Accession No. AY095146.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=21314906> (2006).
Database entry ofHomo sapiensNACHT, leucine rich repeat and PYD containing 12 (NALP12), transcript variant 2, mRNA, Accession No. NM—144687.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=21955153> (2006).
Database entry ofHomo sapiensNALP12 (NALP12) mRNA, complete cds, Accession No. AY154467.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=28436377> (2006).
Database entry ofHomo sapiensNACHT, leucine rich repeat and PYD containing 12, mRNA (cDNA clone MGC:40117 IMAGE:5212737), complete cds, Accession No. BC028069.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=20380399> (2006).
Database entry ofHomo sapienscDNA FLJ38141 fis, clone D9OST2002673, weakly similar toHomo sapienscaspase recruitment domain protein 7 mRNA, Accession No. AK095460.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=21754717> (2006).
Database entry of monarch-1 [Homo sapiens], Accession No. AAM75142.1 <www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=21711821> (2006).
Database entry of PYRIN-containing APAF1-like Protein 7 [Homo sapiens], Accession No. AAM18227 <www.ncbi.nlm.nih.gov/entrez/viewer.fcg
Harton Jonathan A.
Linhoff Michael W.
Moore Christopher B.
Ting Jenny P.-Y
Burkhart Michael
Myers Bigel Sibley & Sajovec P.A.
The University of North Carolina at Chapel Hill
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