Catechol diethers as selective PDE.sup.IV inhibitors

Details Catechol diethers as selective PDE.sup.IV inhibitors Catechol diethers as selective PDE.sup.IV inhibitors

1997-06-10

1998-09-29

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5482686, 5482678, A61K 31415, C07D23506

Patent

active

058146512

ABSTRACT:
This invention relates to 4-substituted catechol diether compounds which are selective inhibitors of phosphodiesterase (PDE) type IV. The compounds of the present invention are useful in inhibiting PDE.sub.IV and in the treatment of AIDS, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases. This invention also relates to pharmaceutical compositions comprising the compounds hereof. ##STR1##

REFERENCES:
patent: 5430062 (1995-07-01), Cushman
patent: 5449687 (1995-09-01), Christensen, IV et al.
patent: 5622977 (1997-04-01), Warrellow
Chemical Abstracts, vol. 117:251066, abstract of EP 497564A1, 1992.
Chemical Abstracts, vol. 115, No. 15, 1991, Abs. No. 158680z.
Chemical Abstracts, vol. 112, No. 19, 1990, Abs. No. 172319h.
Beavo, J. A. et al., TiPS, Apr. 1990, vol. 11, pp. 150-155.
Nicholson, C. D. et al., TiPS, Jan. 1991, vol. 12, pp. 19-27.
Sutherland, E. W. et al., Pharmacol. Rev., 1960, 12, pp. 265-299.
Verghese, M. W. et al., J. Mol. Cell Cadiol., 1989, 12 (Suppl. II), S61.

Affiliated with

Also associated with

Rating

Catechol diethers as selective PDE.sup.IV inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Catechol diethers as selective PDE.sup.IV inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Catechol diethers as selective PDE.sup.IV inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-686677