Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Patent
1994-10-21
1995-12-19
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
514420, 514523, 514525, A61K 31275
Patent
active
054768756
ABSTRACT:
Catechol derivatives of the formula ##STR1## wherein Ra, Rb and Rc have the significance given herein, the ester and ether derivatives thereof which are hydrolyzable under physiological conditions and the pharmaceutically acceptable salts thereof are described and possess valuable pharmacological properties. In particular, they inhibit the enzyme catechol-O-methyltransferase (COMT), a soluble, magnesium-dependent enzyme which catalyses the transference of the methyl group of S-adenosylmethionine to a catechol substrate, whereby the corresponding methyl ethers are formed. Suitable substrates which can be O-methylated by COMT and which can thus be deactivated are, for example, extraneuronal catecholamines and exogeneously-administered therapeutically active substances having a catechol structure.
REFERENCES:
patent: 2199389 (1940-05-01), Britton et al.
patent: 3985783 (1976-10-01), Johnson et al.
patent: 4124726 (1982-11-01), Hamazaki et al.
patent: 4332820 (1984-06-01), Markley
patent: 4622066 (1986-11-01), Kitahara et al.
patent: 4801616 (1989-01-01), Gapinski
patent: 4963590 (1990-10-01), Backstrom et al.
Function and Regulation of Monoamine Enzymes, Basic and Clinical Aspects, MacMillian Publishers, 1981 657-664.
Chemical Abstracts 92, 146461x (1980).
Chemical Abstracts 98, 50111f (1983) and J. Antibiot. 35 (10) 1361-1366 (1982).
J. Pharmacol. Exp. Ther. 174, 83-93 (1970).
Biochem. Pharmacol. 28, 1221-1225 (1979).
Arch. Pharmacol. 320, 34-37 (1982).
J. Med. Chem 25, 258-263 (1982).
J. Med. Chem. 25, 321-323 (1982).
Registry Handbook 1965-1971 p. 10666R.
CA 95: 135254t (1981).
Miyamoto et al., Chem. Abstr. vol. 99 #121998 (1983).
Chem. Abstracts vol. 115, No. 5, Abstract 49134d p. 790 Aug. 5, 1991 Bernauer, et al.
Borgulya et al. Helv. Chim. Acta, vol. 72(5) pp. 952-968 (1989).
Bernauer Karl
Borgulya Janos
Bruderer Hans
Da Prada Mose
Zurcher Gerhard
Davis Zinna N.
Gould George M.
Hoffman-La Roche Inc.
Ivy C. Warren
Johnston George W.
LandOfFree
Catechol derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Catechol derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Catechol derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-992368