Catalytic process for preparing the alkyl esters of ibuprofen

Details Catalytic process for preparing the alkyl esters of ibuprofen Catalytic process for preparing the alkyl esters of ibuprofen

1993-05-11

1994-05-24

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562406, C07C 6976

Patent

active

053150279

ABSTRACT:
A process for preparing alkyl esters of ibuprofen is provided. A 1-halo-1-(4-isobutylphenyl)ethane is reacted in an anhydrous medium with carbon monoxide in the presence of an alkoxide source at a temperature between about 10.degree. C. and about 200.degree. C. An excess of several moles of alcohol is preferred. An acid such as hydrogen chloride may also be added. As catalyst, a palladium compound having at least one acid-stable ligand is present; however, an excess of ligand over palladium is advantageous.

REFERENCES:
patent: 4990658 (1991-02-01), Stahly et al.

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