Process for preparing aryl-substituted aliphatic carboxylic acid

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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562406, 560100, 560 20, 560 21, 560 55, 560 56, C07C 6976

Patent

active

053150260

ABSTRACT:
A catalytic process for preparing aryl substituted aliphatic carboxylic acid esters is disclosed. A 1-aryl substituted olefinic compound is reacted with carbon monoxide in the presence of an alcohol in anhydrous conditions at a temperature between about 25.degree. C. and about 200.degree. C. An excess of several moles of anhydrous alcohol is preferred. An acid such as hydrochloric acid may also be added. As catalyst, a mixture of a palladium compound and a copper compound is used with at least one acid-stable cyclic phosphine having the formula: ##STR1## where R' is the same or different than R" and is alkyl or aryl, said aryl, either substituted or unsubstituted, and Ar' is phenyl, naphthyl, substituted phenyl or substituted naphthyl and n is an integer from 3 to 6.

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