Catalytic hydrogenolysis of protected sulfur containing peptides

Details Catalytic hydrogenolysis of protected sulfur containing peptides Catalytic hydrogenolysis of protected sulfur containing peptides

1974-03-20

1976-06-01

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603067R, 260534S, C07C10352, C07G 700

Patent

active

039608280

ABSTRACT:
The use of catalytic hydrogenolysis to selectively deblock protected moieties in sulfur containing compounds has not been a practical process due to poisoning of the catalyst by the sulfur compound. It has now been found that catalytic hydrogenolysis of sulfur compounds can be successfully carried out by conducting the reaction in liquid ammonia as solvent.

REFERENCES:
duVigneaud et al.: J. Am. Chem. Soc., 52, 4500-4504, (1930).
Doyle et al.: J. Chem. Soc., 1440-1444, (1962).
DeHaas et al.: Rec. Trav. Chim. Pays-Bas, 81, 215-218, (1962).
Berse et al.: J. Org. Chem., 22, 805- 808, (1957).

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