Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1990-03-23
1993-07-20
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
4351885, 435219, 435226, 5303892, 5303871, 53038824, C12N 900, C12N 964, C12P 2106
Patent
active
052292720
ABSTRACT:
Catalytic antibody components, methods for producing catalytic antibody components, methods for using catalytic antibody components, in particular, single chain and smaller components are disclosed. Catalytic antibody components able to promote the cleavage or formation of an amide, peptide, ester or glycosidic bond, and which are prepared from monoclonal catalytic antibodies, catalytic autoantibodies or by site-directed mutagenesis are disclosed. Methods of using catalytic antibody components alone or in combination with other antibody components or other biological moieties are disclosed.
REFERENCES:
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4492751 (1985-01-01), Boguslaski et al.
patent: 4493890 (1985-01-01), Morris
patent: 4659567 (1987-04-01), Tramontano et al.
patent: 4661586 (1987-04-01), Levy et al.
patent: 4792446 (1988-12-01), Kim et al.
patent: 4888281 (1989-12-01), Schochetman et al.
patent: 4900674 (1990-02-01), Benkovic et al.
Klein, J., Immunology, John Wiley & Sons, N.Y., 1982, pp. 168-169.
Baldwin, E., et al., 21 (1989) Science 245, 1104-1107.
Jackson, D. Y. et al. (1991) Proc. Natl. Acad. Sci., USA, 88(1), 58-62.
Berchtold et al., Blood vol. 74, No. 7, pp. 2414-2417 (1989).
Itoh et al., Nature, vol. 304, pp. 547-549 (1983).
Altschuh, D. et al., "Localization of Antigenic Determinants of a Viral Protein by Inhibition of Enzyme-Linked Immunosorbent Assay (ELISA) with Tryptic Peptides", J. Immunology Methods, vol. 50, p. 99 (1982).
Amit, A. G. et al., "Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 A Resolution", Science 233: 747 (1986).
Amzel, L. M. et al., "Three-Dimensional Structure of Immunoglobulins", Ann. Rev. Biochem, 48:961 (1979).
Anglister, J. et al., "NMR study of the Complexes Between a Synthetic Peptide Derived from the B Subunit of Cholera Toxin and Three Monoclonal Antibodies Against It", Abstract, American Chemical Soc. (1988), 006-2960/88/0427-0717.
Aruffo, A. et al., "Molecular Cloning of a CD38 cDNA by a high-efficiency COS cell expression system", Proc. Natl. Acad. Sci., 84: 8573-8577 (1987).
Atassi, M. Z., "Surface-Simulation Synthesis and Its Application in Protein Molecular Recognition", Protein Engineering--Applications in Science, Medicine and Industry, pp. 125-153 Edited by Inouye, M. and Sarma, R., Academic Press (1986).
Azuma, T. et al., "Diversity of the Variable-Joining Region Boundary of .lambda. Light Chains has a Pronounced Effect on Immunoglobulin Ligand-Binding Activity", Proc. Natl. Acad. Sci. USA, v. 81, p. 6139, (Oct. 1984).
Barrett, A. J., Proteinase Inhibitors (Editors A. J. Barrett and G. Salvesen), pp. 3-22, Elsevier, London, (1986).
Baum, R., "Catalytic Antibody Cuts Peptide Bond", C & E N, 5, 7-8 (1989).
Benjamini, E. et al., "Immunochemical Studies on the Tobacco Mosaic Virus Protein. VI. Characterization of Antibody Population Following Immunization with TMV Protein", Biochemistry, v. 7, No. 4, pp. 1253-1260 (1968).
Benjamini, E. et al., "Immunochemical Studies on the Tobacco Mosaic Virus Protein. VII. The Binding of Octanoylated Peptides of the TMV Protein with Antibodies to the Whole Protein", Biochemistry, v. 7, No. 4, pp. 1261-1264 (1968).
Better, M. et al., "Escherichia Coli Secretion of an Active Chimeric Antibody Fragment", Science, 240: 1041-1043 (1988).
Blackburn, G. M. et al., "Catalytic Antibodies", Biochem. J. 262: 381 (1989).
Burd, J. et al., "Specific Protein-Binding Reactions Monitored by Enzymatic Hydrolysis of Ligands-Fluorescent Dye Conjugates", Analytical Biochemistry, 77, 56-67 (1977).
Chalufour, A. et al., "Rare Sequence Motifs are Common Constituents of Hypervariable Antibody Regions", Ann. Inst. Pasteur/Immunology, 138:671, Elsevier, Paris (1987).
Chaudhary, V. J. et al., "A recombinant immunotoxin consisting of two antibody variable domains fused to Psuedomonas exotoxin", Nature 339: 394 (1989).
Chothia, C. et al., "Canonical Structures for the Hypervariable Regions of Immunoglobulins", J. Mol. Biol. 196: 901 (1987).
Chothia, C. et al., "The Predicted Structure of Immunoglobulin D1.3 and Its Comparison with the Crystal Structure", Reports, 755 (Aug. 1986).
Cochran, A. G. et al., "Photosensitized Cleavage of a Thymine Dimer by an Antibody", J. Am. Chem. Soc., 110: 7888-7890 (1988).
Colman, P. M. et al., "Three-Dimensional Structure of a Complex of Antibody with Influenza Virus Neuraminidase", Nature 326: 358 (Mar. 1987).
Corey, D. R. et al., "Generation of a Hybrid Sequence-Specific Single-Stranded Deoxyribonuclease", Reports 1401 (Dec. 1987).
David G. S. et al., "The Hybridoma-An Immunochemical Laser", Clin. Chem., 27 (9), 1580-1585 (1981).
de La Paz, P. et al., "Modelling of the Combining Sites of Three Anti-Lysozyme Monoclonal Antibodies and of the Complex Between One of the Antibodies and its Epitope", EMBO J., 5:2, 415 (1986).
Dimaline, R. et al., "A novel VIP from elasmobranch intestine has full affinity for mammalian pancreatic VIP receptors", Biochimica et Biophysica Acta, 930, 97-100 (1987).
Dimaline, R. et al., "Purification and Characterization of VIP from Two Species of Dogfish", Peptides, 7 (Suppl. 1): 21-26 (1986).
Dixon, M. et al., Enzymes, Third Edition, London, (1979) index only.
Durfor, C. N. et al., "Antibody Catalysis in Reverse Micelles", J. Am. Chem. Soc. 110, 8713 (1988).
Edelman, G. M. et al., "Reconstitution of Immunologic Activity by Interaction of Polypeptide Chains of Antibodies", Proc. Natl. Acad. Sci., 50: 753-761 (1963).
Emr, S. D. et al., "Sequence analysis of mutations that prevent export of .lambda. receptor, an Escherichia coli outer membrane protein", Nature, 285: 82-85 (1980).
Ehran, S. et al., "Do immunoglobulins have proteolytic activity?", Nature, v. 251, pp. 353-355 (Sep. 27, 1974).
Frackelton, Jr., A. R., et al., "Functional Diversity of Antibodies Elicited by Bacterial .beta.-D Galactosidase", J. Bio. Chem., 255 (11), 5286-5290 (1980).
Franek, F. and Nezlin, R. S., "Recovery of Antibody Combining Activity By Interaction of Different Peptide Chains Isolated from Purified Horse Antitoxins", Folia Microbiol., 8: 128-130 (1963).
Gavish, M. et al., "Preparation of a Semisynthetic Antibody", Abstract, Am. Chem. Soc. (1978), 006-2960/78/0417-1345.
Geysen, H. M. et al., "A Priori Delineation of a Peptide Which Mimics a Discontinuous Antigenic Determinant", Molecular Immunology, 23:7 p. 709 (1986).
Giam, C. Z. et al., "In Vivo and In Vitro Autoprocessing of Human Immunodeficiency Virus Protease Expressed in Escherichia Coli", J. Biol. Chem., 263: 14617-14620 (1985).
Gish et al., J. Med. Chem., 14: 1159-1162 (1971).
Hansen, D., "Antibodies with Some Bite", Nature, 325, 304 (1987).
Harper, J. W. et al., "Enzymatically Active Angiogenin/Ribonuclease A Hybrids Formed by Peptide Interchange", Abstract, Am. Chem. Soc. (1988), 006-2960/88/0427-0219.
Hendershot, L. M. et al., "Identity of the Immunoglobulin Heavy-Chain-Binding Protein with the 78,000-Dalton Glucose-Regulated Protein and the Role of Posttranslational Modifications in Its Binding Function", Mol. and Cellular Bio., 8(10), 4250-4256, (1988).
Highfeld, R., "AIDS Drug A Step Nearer", The Daily Telegraph, 9, (Aug. 4, 1987).
Hilvert, D. et al., "Catalysis of Concerted Reactions by Antibodies: The Claisen Rearrangement", Proc. Natl. Acad. Sci. USA, v. 85, pp. 4953-4955 (Jul. 1988).
Hochman, J. et al., "An Activity Antibody Fragment (Fv) Composed of the Variable Portions of Heavy and Light Chains", Biochemistry 12: 1130 (1973).
Huse, W. D. et al., "Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phase Lambda", Science, 246: 1275-1281 (1989).
Inbar, D. et al., "Localization of Antibody-Combining Sites within the Variable Portions of Heavy and Light Chains", Proc. Natl. Acad. Sci. USA, 69: 2659 (1972).
Inbar, D. et al., "Crystallization with Hapten of the Fab Fragment from a Mouse IgA Myeloma Protein with Antidinitrophenyl Activity", J. of Biol. Chem. 246: 6272 (1971).
Iverson, B. L. et al., "Sequence-Specific Peptide Cleavage Catalyzed by an Antibody", Science 243:1184 (1989).
Jackson, D. Y. et al., "An An
Kenten John H.
Massey Richard J.
Paul Sudhir
Powell Michael J.
Evans Barry
IGEN, Inc.
Patterson Jr. Charles L.
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