Carboxylic acid compound having condensed ring, salt thereof and

Details Carboxylic acid compound having condensed ring, salt thereof and Carboxylic acid compound having condensed ring, salt thereof and

1997-03-26

1998-05-19

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514211, 514301, 514302, 540597, 546113, 546114, 546115, A61K 3155, A61K 3144, C07D47102, C07D49802

Patent

active

057536708

ABSTRACT:
A novel carboxylic acid compound having a condensed ring; which is represented by the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof and pharmaceutical use thereof. The novel carboxylic acid compound having a condensed ring and pharmacologically acceptable salt thereof of the present invention have superior GPIIb/IIIa antagonism in mammals inclusive of human; can be administered orally; have long life in blood and low toxicity; and show less side-effects. Accordingly, they are extremely useful for the prophylaxis and treatment of thrombotic diseases and other diseases.

REFERENCES:
patent: 4800211 (1989-01-01), Tischler et al.
patent: 5068226 (1991-11-01), Weinshenker et al.
patent: 5118680 (1992-06-01), Muller et al.
patent: 5576343 (1996-11-01), Nagahara et al.
patent: 5656638 (1997-08-01), Gaeta et al.
Journal of Medicinal Chemistry, vol. 35, No. 23, Nov. 13, 1992, pp. 4393-4407.

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