Carbostyril derivatives as combined thromboxane synthetase and c

Details Carbostyril derivatives as combined thromboxane synthetase and c Carbostyril derivatives as combined thromboxane synthetase and c

1988-09-21

1990-05-01

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546157, 546158, 546 13, A61K 3147, C07D40106, C07D40110, C07D40112

Patent

active

049218620

ABSTRACT:
The invention concerns a method of inhibiting both thromboxane synthetase and cyclic-AMP phosphodiesterase in a mammal having a disease characterized by elevated thromboxane levels or an imbalance of prostacyclin/thromboxane levels with a compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt or ester thereof, wherein:

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