Carbohydrate-based anti-inflammatory agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 54, 514 62, 536 53, 536 55, 536 551, 536 552, 536123, A61K 31725

Patent

active

054708427

ABSTRACT:
Ligands in the form of N-acetyllactosamines which bind to endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. The ligand compounds can be formulated into pharmaceutical compositions and/or assay compositions used to alleviate inflammation and assay for the presence of (qualitative) and amount of (quantitative) ELAM-1 and thereby determine the presence, location and degree of inflammation.

REFERENCES:
patent: 4330299 (1982-05-01), Cerami
patent: 5011920 (1991-04-01), Hakomori et al.
patent: 5296594 (1994-03-01), Ratcliffe et al.
patent: 5344870 (1994-09-01), Ratcliffe et al.
European Search Report.
Lamblin et al., Journal of Biological Chemistry (1984) 259(14):9051-9058.
Michalski et al., FEBS Letters (1977) 79(1):101-104.
Brandley et al., Cell (1990) 63:861-863.
Gnewuch et al., Chem. Rev. (1986) 86:203-238.
Brandley and Schnarr, J. Leuk. Biol., 40:97-111 (1986).
Sharon and Lis, Science, 246:227-246, (1989).
Dodd and Jessel, J. Neurosci. 5:3278-3294 (1985).
Regan et al., Proc. Natl. Acad. Sci. USA, 83:2248-2252 (1986).
Constantine-Paton et al., Nature, 324:459-462 (1986).
Tiemeyer et al., J. Biol. Chem., 263:1671-1681 (1989).
Bevilacqua et al., Proc. Natl. Acad. Sci. USA, 84:9238-9242 (1987).
Fukuda et al., J. Biol. Chem., 261:2376-2383 (1986).
Magnani et al., J. Biol. Chem., 257:14365-14369 (1982).
Hakomori et al., Biochem. Biophys. Res. Comm., 113:791-798 (1983).
Fukushi et al., J. Exp. Med., 160:506-520 (1984).
Geng et al., Nature, 343:757-760 (1990).
Johnston et al., Cell, 56:1033-1044 (1989).
Geoffroy and Rosen, J. Cell. Biol., 109:2463-2469 (1989).
Lasky et al., Cell, 56:1045-1055 (1989).
Bevilacqua et al., Science, 243:1160-1165 (1989).
Slomiany et al; Biochim. Biophys. Acta 388:135-145 (1975).
Kannagi et al; J. Biol. Chem. 258(14):8934-8942 (1983).
Hansson et al; J. Biol. Chem. 258(7):4091-4097 (1983).
Fukushi et al; J. Biol. Chem. 259(7):4681-4685 (1984).
Fenderson et al; J. Exp. Med. 160:1591-1596 (1984).
Fukushi et al; J. Biol. Chem. 259(16):10511-10517 (1984).
Gooi et al; J. Biol. Chem. 260(24):13218-13224 (1985).
Hansson et al; J. Biol. Chem. 260(16):9388-9392 (1985).
Magnani; Chem. Phys. Lipids 42:65-74 (1986).
Fukuda et al; J. Biol. Chem. 261(5): 2376-2383 (1986).
Claussen et al; J. Immunol. 136(1):326-330 (1986).
Kitagawa et al; J. Biochem. 104:591-594 (1988).
Macher et al; J. Biol. Chem. 263(21):10186-10191 (1988).
Amico-Roxas et al; Arch. Int. Pharmacodyn. 291:238-252 (1988).
Stanley et al; J. Biol. Chem. 263(23):11374-11381 (1988).
Prokazova et al; Eur. J. Biochem. 172:1-6 (1988).
Lemieux et al; Carb. Res. 178:293-305 (1988).
Stults et al; Meth. Enzymol. 179:167-213 (1989).
Eggens et al; Biochem. Biophys. Res. Commun. 158(3):913-920 (1989).
Eggens et al; J. Biol. Chem. 264(16):9476-9484 (1989).
Phillips et al; Science 250:1130-1132 (Nov. 23, 1990).
Walz et al; Science 250:1132-1135 (Nov. 23, 1990).
Lowe et al; Cell 63:475-484 (Nov. 2, 1990).
Handa et al; Biochem. Biophys. Res. Commun. IBI(3):1223-30 (Dec. 31, 1991).
Berg et al; J. Exp. Med. 174:1461-1466 (Dec. 1991).
Picker et al; Cell 66:921-933 (Sep. 6, 1991).
Baeckstrom et al: J. Biol. Chem. 266(32):21537-21547 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Carbohydrate-based anti-inflammatory agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Carbohydrate-based anti-inflammatory agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbohydrate-based anti-inflammatory agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2013761

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.