Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1992-03-02
1995-11-28
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 54, 514 62, 536 53, 536 55, 536 551, 536 552, 536123, A61K 31725
Patent
active
054708427
ABSTRACT:
Ligands in the form of N-acetyllactosamines which bind to endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. The ligand compounds can be formulated into pharmaceutical compositions and/or assay compositions used to alleviate inflammation and assay for the presence of (qualitative) and amount of (quantitative) ELAM-1 and thereby determine the presence, location and degree of inflammation.
REFERENCES:
patent: 4330299 (1982-05-01), Cerami
patent: 5011920 (1991-04-01), Hakomori et al.
patent: 5296594 (1994-03-01), Ratcliffe et al.
patent: 5344870 (1994-09-01), Ratcliffe et al.
European Search Report.
Lamblin et al., Journal of Biological Chemistry (1984) 259(14):9051-9058.
Michalski et al., FEBS Letters (1977) 79(1):101-104.
Brandley et al., Cell (1990) 63:861-863.
Gnewuch et al., Chem. Rev. (1986) 86:203-238.
Brandley and Schnarr, J. Leuk. Biol., 40:97-111 (1986).
Sharon and Lis, Science, 246:227-246, (1989).
Dodd and Jessel, J. Neurosci. 5:3278-3294 (1985).
Regan et al., Proc. Natl. Acad. Sci. USA, 83:2248-2252 (1986).
Constantine-Paton et al., Nature, 324:459-462 (1986).
Tiemeyer et al., J. Biol. Chem., 263:1671-1681 (1989).
Bevilacqua et al., Proc. Natl. Acad. Sci. USA, 84:9238-9242 (1987).
Fukuda et al., J. Biol. Chem., 261:2376-2383 (1986).
Magnani et al., J. Biol. Chem., 257:14365-14369 (1982).
Hakomori et al., Biochem. Biophys. Res. Comm., 113:791-798 (1983).
Fukushi et al., J. Exp. Med., 160:506-520 (1984).
Geng et al., Nature, 343:757-760 (1990).
Johnston et al., Cell, 56:1033-1044 (1989).
Geoffroy and Rosen, J. Cell. Biol., 109:2463-2469 (1989).
Lasky et al., Cell, 56:1045-1055 (1989).
Bevilacqua et al., Science, 243:1160-1165 (1989).
Slomiany et al; Biochim. Biophys. Acta 388:135-145 (1975).
Kannagi et al; J. Biol. Chem. 258(14):8934-8942 (1983).
Hansson et al; J. Biol. Chem. 258(7):4091-4097 (1983).
Fukushi et al; J. Biol. Chem. 259(7):4681-4685 (1984).
Fenderson et al; J. Exp. Med. 160:1591-1596 (1984).
Fukushi et al; J. Biol. Chem. 259(16):10511-10517 (1984).
Gooi et al; J. Biol. Chem. 260(24):13218-13224 (1985).
Hansson et al; J. Biol. Chem. 260(16):9388-9392 (1985).
Magnani; Chem. Phys. Lipids 42:65-74 (1986).
Fukuda et al; J. Biol. Chem. 261(5): 2376-2383 (1986).
Claussen et al; J. Immunol. 136(1):326-330 (1986).
Kitagawa et al; J. Biochem. 104:591-594 (1988).
Macher et al; J. Biol. Chem. 263(21):10186-10191 (1988).
Amico-Roxas et al; Arch. Int. Pharmacodyn. 291:238-252 (1988).
Stanley et al; J. Biol. Chem. 263(23):11374-11381 (1988).
Prokazova et al; Eur. J. Biochem. 172:1-6 (1988).
Lemieux et al; Carb. Res. 178:293-305 (1988).
Stults et al; Meth. Enzymol. 179:167-213 (1989).
Eggens et al; Biochem. Biophys. Res. Commun. 158(3):913-920 (1989).
Eggens et al; J. Biol. Chem. 264(16):9476-9484 (1989).
Phillips et al; Science 250:1130-1132 (Nov. 23, 1990).
Walz et al; Science 250:1132-1135 (Nov. 23, 1990).
Lowe et al; Cell 63:475-484 (Nov. 2, 1990).
Handa et al; Biochem. Biophys. Res. Commun. IBI(3):1223-30 (Dec. 31, 1991).
Berg et al; J. Exp. Med. 174:1461-1466 (Dec. 1991).
Picker et al; Cell 66:921-933 (Sep. 6, 1991).
Baeckstrom et al: J. Biol. Chem. 266(32):21537-21547 (1991).
Brandley Brian K.
Moreland Margaret
Schweingruber Hans
Swiedler Stuart J.
Tiemeyer Michael
Bozicevic Karl
Fonda Kathleen Kahler
Giotta Gregory J.
Glycomed Incorporated
Gregg Valeta
LandOfFree
Carbohydrate-based anti-inflammatory agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carbohydrate-based anti-inflammatory agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbohydrate-based anti-inflammatory agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2013761