Carbapenem derivatives

Details Carbapenem derivatives Carbapenem derivatives

1996-02-13

1996-12-10

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D48701

Patent

active

055832180

ABSTRACT:
Carbapenem derivatives of formula (I): ##STR1## wherein (a) R.sub.1 is a hydrogen atom, an alkyl group of from 1 to 6 carbon atoms, a hydroxy-lower alkyl group or a protected hydroxy-lower alkyl group of from 1 to 6 carbon atoms in its alkyl moiety, (b) COOR.sub.2 is a carboxyl group, a carboxylate anion or a protected carboxyl group, (c) R.sub.3 is an alkyl group of from 1 to 6 carbon atoms and (d) R.sub.4 is a substituted or unsubstituted heterobicyclic group of formula (II): ##STR2## in which the partial structure ##STR3## is a 5- or 6-membered, saturated or unsaturated, nitrogen-containing heterocycle containing 1 to 4 hereto atoms each selected from the group consisting of oxygen, sulfur and nitrogen, at least one hetero atom being nitrogen, and is which R.sub.5 and R.sub.6 each is a hydrogen atom or an appropriate substituent, any isomeric form thereof, and pharmacologically acceptable salts thereof are potent and stable antimicrobial agents.

REFERENCES:
Chemical Abstracts, vol. 107, No. 19, Nov. 9, 1987, p. 697, Abstract No. 175781k, Columbus, Ohio, US.

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