Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-09-10
1999-11-30
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540302, A61K 31425, A61K 31395, C07D48704
Patent
active
059943432
ABSTRACT:
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a --Z--CH.sub.2 group. The naphthosultam is further substituted with various substituent groups including cationic groups. The compounds are represented by formula I: ##STR1## Pharmaceutical compositions and methods of use are also included.
REFERENCES:
patent: 5756725 (1998-05-01), Wilkening et al.
S. M. Schmitt et al. J. Antibiotics, 41(6), pp. 780-787 (1988).
Bioorganic & Medicinal Chem.Ltrs, 6, p. 2449, (1996).
A. G. M. Barrett et al., J. Org Chem. 40 p. 1679 (1994).
T. W. Green, Protective Group Inorganic Synethesis, Wiley, NY (1991).
DiNinno Frank P.
Dykstra Kevin D.
Ayler Sylvia A.
Daniel Mark R.
Hunter, Jr. James M.
Kessinger Ann M.
Merck & Co. , Inc.
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