Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2003-04-03
2009-12-08
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S255010, C544S359000, C544S360000, C544S373000, C544S377000, C544S383000
Reexamination Certificate
active
07629343
ABSTRACT:
This invention pertains to certain carbamic acid compounds which inhibit HDAC (histone deacetylase) activity of the following formula:wherein: Cy is independently a cyclyl group; Q1is independently a covalent bond or cyclyl leader group; the piperazin-1,4-diyl group is optionally substituted; J1is independently a covalent bond or —C(═; O)—; J2is independently —C(═O)— or —S(═O)2—; Q2is independently an acid leader group; wherein: Cy is independently: C3-20carbocyclyl, C3-20heterocyclyl, or C5-20aryl; and is optionally substituted; Q1is independently: a covalent bond; C1-7alkylene; or C1-7alkylene-X—C1-7alkylene, —X—C1-7alkylene, or C1-7alkylene-X—, wherein X is —O— or —S—; and is optionally substituted; Q2is independently: C4-8alkylene; and is optionally substituted; and has a backbone length of at least 4 atoms; or: Q2is independently: C5-20arylene; C5-20arylene-C1-7alkylene; C1-7alkylene-C5-20arylene; or, C1-7alkylene-C5-20arylene-C1-7alkylene; and is optionally substituted; and has a backbone length of at least 4 atoms; or a pharmaceutically acceptable salt, solvate, amide, ester, ether, chemically protected form, or prodrug thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.
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Dikovska Klara
Finn Paul W
Gailite Vija
Kalvinsh Ivars
Lolya Daina
Leeser Erich A
Nixon & Vanderhye P.C.
Topotarget UK Limited
Wilson James O
LandOfFree
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