Cancer therapy utilizing ex vivo gene transduction

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

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424 932, 4242771, 4353201, 435375, 435366, A61K 4800, C12N 1500, C12N 1563, C12N 500

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061104582

ABSTRACT:
A method is provided for eliminating cancer cells from a population of cells containing cancer cells and noncancerous cells in vitro or in vivo comprising: (a) providing a mixture of noncancerous cells and cancer cells; (b) contacting the cancer cells with transgenic cancer cells comprising a foreign gene that renders the transgenic cancer cells susceptible to a therapeutic agent; and (c) contacting the transgenic cancer cells with an amount of said therapeutic agent effective to kill both the transgenic cancer cells and the cancer cells.

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