IGF-1 to improve the neural condition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 12, A61K 3828

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active

058613730

ABSTRACT:
A method of treating injuries to or diseases of the central nervous system that predominantly affects glia and/or non-cholinergic neuronal cells characterized in that it comprises the step of increasing the active concentration(s) of insulin-like growth factor 1 and/or analogues thereof in the central nervous system of the patient. The present invention also provides therapeutic compositions comprising insulin-like growth factor 1 and/or analogues thereof for administration to a patient at or following a neural insult, which compositions are useful in minimizing damage to the central nervous system that would otherwise occur following the insult.

REFERENCES:
patent: 5093317 (1992-03-01), Lewis et al.
Beck et al., "Igfl Gene Disruption Results in Reduced Brain Size, CNS Hypomyelination, and Hippocampal Granule and Striatal Parvalbumin-Contatining Neurons" Neuron 14:717-730 (Apr. 1995).
Carson et al., "Insulin-like Growth Factor I Increases Brain Growth and Central Nervous System Myelination in Transgenic Mice" Neuron 10:729-740 (Apr. 1993).
ffrench-Constant, Charles, "Pathogenesis of multiple sclerosis" Lancet 343:271-274 Jan. 29, 1994).
Grinspan et al., "Protein Growth Factors as Potential Therapies for Central Nervous System Demyelinative Disorders" Annals of Neurology (Supplement to Volume 36) pp. 140-142 (1994).
Bejar et al., "Anatenatal origin of neurologic damage in newborn infants" Am. J. Obstet. Gynecol. 159(2):357-362 (Aug. 1988).
Bohannon et al., "Localization of binding sites for insulin-like growth factor-1 (IGF-1) in the rat brain by quantitative autoradiography" Brain Research 444:205-213 (1988).
Bondy et al., "Cellular pattern of type-1 insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II" Neurosci. 46(4):909-923 (1992).
Brownstein et al. Handbook of Chemical Neuroanatomy, Classical Transmitters in the CNS, Bjorklund et al., Elsevier, Amsterdam pp. 23-54 (1984).
Gluckman et al., "A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury" Biochem. & Biophys. Res. Comm. 182(2):593-599 (Jan. 31, 1992).
Guler et al., "Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects" Proc. Natl. Acad. Sci. USA 86:2868-2872 (Apr. 1989).
Guler et al., "Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults" New England J. of Medicine 317(3):137-140 (Jul. 16, 1987).
Hill et al., "Autoradiographic Localization of Insulin Receptors in Rat Brain: Prominence in Olfactory and Limbic Areas" Neurosci. 17(4):1127-1138 (1986).
Kanje et al., "Insulin-like growth factor I (IGF-1) stimulates regeneration of the rat sciatic nerve" Brain Research 486:396-398 (1989).
Kiess et al., "Rat C6 Glial Cells Synthesize Insulin-Like Growth Factor I (IGF-I) and Express IGF-I Receptors and IGF-II/Mannose 6-Phosphate Receptors" Endocrinology 124(4):1727-1736 (1989).
Knusel et al., "Selective and Nonselective Stimulation of Central Cholinergic and Dopaminergic Development in vitro by Nerve Growth Factor, Basic Fibrablast Growth Factor, Epidermal Growth Factor, Insulin and the Insulin-like Growth Factors I and II" J. Neurosci. 10(2):558-570 (Feb. 1990).
Lesniak et al., "Receptors for Insulin-like Growth Factors I and II: Autoradiographic Localization in Rat Brain and Comparison to Receptors for Insulin" Endocrinology 123(4):2089-2099 (1988).
McMorris et al., "Insulin-Like Growth Factor I Promotes Cell Proliferation and Oligodendrogilial Commitment in Rat Glial Progenitor Cells Developing In Vitro" J. Neurosci. Res. 21:19-209 (1988).
McMorris et al., "Insulin-like growth factor I/somatomedin C: A potent inducer of oligodendrocyte development" Proc. Natl. Acad. Sci. USA 83:822-826 (Feb. 1986).
Mesulam et al., "Atlas of Cholinergic Neurons in the Forebrain and Upper Brainstem of the Macaque Based on Monoclonal Choline Acetyltransferase Immunohistochemistry and Acetylcholinesterase Histochemistry" Neurosci. 12(3):669-686 (1984).
Mozell et al., "Insulin-Like Growth Factor I Stimulates Oligodendrocyte Development and Myelination in Rat Brain Aggregate Cultures" J. Neurosci. Res. 30:382-390 (1991).
Philipps et al.. "The Effects of Biosynthetic Insulin-Like Growth Factor-1 Supplementation on Somatic Growth, Maturation, and Erythropoiesis on the Neonatal Rat" Pediatric Res. 23(3):298-305 (1988).
Scheiwiller et al., "Growth restoration of insulin-deficient diabetic rats by recombinant human insulin-like growth factor I" Nature 323:169-171 (Sep. 11 1986).
Sinha et al., "Ischaemic brain lesions diagnosed at birth in preterm infants: clinical events and developmental outcome" Arch. Dis. Child. 65:1017-1020 (1990).
Skottner et al., "Growth Responses in a Mutant Dwarf Rat to Human Growth Hormone and Recombinant Human Insulin-Like Growth Factor I" Endocrinology 124(5):2519-2526 1989).
Skottner et al., "Recombinant human insulin-like growth factor: testing the somatomedin hypothesis in hypophysectomized rats" J. Endocr. 112:123-132 (1987).
Sturm et al., "Insulin-Like Growth Factor Receptors and Binding Protein in Rat Neuroblastoma Cells" Endocrinology 124(1):388-396 (1989).
Svrzic et al., "Insulin-like growth factor 1 supports embryonic nerve cell survival" Biochem. & Biophys. Res. Comm. 172(1):54-60 (Oct. 15, 1990).
Tanner et al., "Comparative rapidity of response of height, limb muscle, and limb fat to treatment with human growth hormone in patients with and without growth hormone deficiency" Acta Endrocrinologica 84:681-696 (1977).
Uthne et al., "Effects of Human Somatomedin Preparations on Membrane Transport and Protein Synthesis in the Isolated Rat Diaphragm" J. Clin. Endocrinol. Metab. 39(3):548-554 (1974).
van Buul-Offers et al., "Biosynthetic Somatomedin C(SM-C/IGF-I) Increases the Length and Weight of Snell Dwarf Mice" Pediatr. Res. 20(9):825-827 (1986).
Werther et al., "Localization of Insulin-Like Growth Factor-I mRNA in Rat Brain by in Situ Hybridization--Relationship to IGF-I Receptors" Mol. Endocrinol. 4(5):773-778 (1990).
Yamaguchi et al., "Increase of extracellular insulin-like growth factor I (IGFI) concentration following electrolytical lesion in rat hippocampus" Neuroscience Letters 128:373-276 (1991).
Young et al., "Selective Reduction of Blood Flow to White Matter During Hypotension in Newborn Dogs: A Possible Mechanism of Preiventricular Leukomalacia" Ann. Neurol. 12(5):445-448 (Nov. 1982).

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