Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Patent
1990-08-06
1992-09-29
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
424639, 424641, 424682, A61K 3306, A61K 3330, A61K 3332, A61K 3334
Patent
active
051512742
ABSTRACT:
Nutritional mineral supplements comprising calcium citrate malate and salts of manganese, copper and zinc are disclosed. These supplements, which provide at least 25% RDA of the minerals, and used in addition to the normal diet. These supplements are useful for increasing bone growth and for treating age-related bone loss in humans and animals.
REFERENCES:
patent: 3949098 (1976-04-01), Bangert
patent: 3950547 (1976-04-01), Lamar, III et al.
patent: 3992555 (1976-11-01), Kovacs
patent: 4070488 (1978-01-01), Davis
patent: 4107346 (1978-08-01), Kravitz
patent: 4214996 (1980-07-01), Buddemeyer et al.
patent: 4351735 (1982-09-01), Buddemeyer et al.
patent: 4419369 (1983-12-01), Nichols et al.
patent: 4497800 (1985-02-01), Larson et al.
Yano, K. et al., Am. J. Clin. Nutr. 42:877-88. "The relationship between diet and bone mineral content . . ."1985.
Holbrook, T. L. et al., Lancet 2:1046-9 "Dietary calcium and risk of hip fracture" 1988.
Peck, William A. et al., Physician's Resource Manual on Osteoporosis, 1987.
Hughes et al., "Effects of Calcium Carbonate and Hydroxyapatite on Zinc and Iron Retention in Postmenopausal Women, American Journal of Clinical Nutrition," Jul. 1986, pp. 83-88.
S. V. Ting, "Nutrients and Nutrition of Citrus Fruits", ACS, 1980 Hungerford et al., "Interactions of pH and Ascorbate in Intestinal Iron Absorption" American Institute of Nutrition, 1983, pp. 2615-2622.
Riis et al., "Does Calcium Supplementation Prevent Postmenopausal Bone Loss?", New England J. of Medicine, 316, pp. 173-177 (1987).
L. Nilas et al., "Calcium Supplementation and Postmenopausal Bone Loss", British Medical Journal, 289, pp. 1103-1106 (1984).
H. Spencer et al., "NIH Concensus Conference: Osteoporosis", Journal of Nutrition, 116, pp. 316-319 (1986).
R. C. Haynes, Jr. et al., "Agents Affecting Calcification", Pharmacological Basis of Therapeutics, (1985), 7th Ed. pp. 1517-1543.
G. D. Whedon et al., "An Analysis of Current Concepts and Research Interests in Osteoporosis", Current Advances in Skeletogenesis, (1985), pp. 327-333.
Reginster et al., "Trace Elements and Postmenopausal Osteoporosis: A Preliminary Study of Decreased Serum Manganese", Med. Sci. Res., 16, pp. 337-338 (1988).
Strause et al., "The Effect of Deficiencies of Manganese and Copper on Osteoinduction and on Resorption of Bone Particles in Rate", Calcif. Tissue Int. 41, pp. 145-150 (1987).
Smith, K. T. et al., Calcium absorption from a new calcium delivery system (CCM) Calcif. Tissue Int. 1987; 41:351-2.
Miller, J. Z. et al., Calcium absorption from calcium carbonate and a new form of calcium (CCM) in healthy male and female adolescents. Am. J. Clin. Nutr. 1988; 48:1291-4.
Miller, J. Z. et al., Calcium absorption in children estimated from single and double stable calcium isotope techniques. Dlinica Chemical Acta 1989; 183:107-14.
Dawson-Hughes, B. et al., A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women, N. Engl. J. Med. 1990; 323:878-83.
Kochanowski B. A., Effect of calcium citrate-malate on skeletal development in young, growing rats. J. Nutr. 1990; 120:876-81.
Kanerva, R. L. et al., Bioavailability of calcium from supplemental and food fortification sources, FASEB J. 1989; 3:A771.
Kanerva, R. L. et al. Assessing human bioavailability potentials of calcium sources using a rat model. J. Bone Min. Res. 1990; 5:S176.
Sheikh, M. S. et al. Gastrointestinal absorption of calcium from milk and calcium salts. N. Engl. J. Med. 1987; 217; 532-6.
Sheikh, M. S. et al. Reduction of dietary phosphorus absorption by phosphorus binders: a theoretical, in vitro, and in vivo study, J. Clin. Invest. 1989; 83:66-73.
Garcia-Lopez, S. et al., Bioavailability of calcium from four different sources. Nutr. Res. 1991; 11:1187-96.
Recker, R. R. Calcium absorption and achlorhydria. N. Eng. J. Med. 1985; 313:70-3.
Bo-Linn, G. W. et al., An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium. J. Clin. Invest. 1984; 73:7640-47.
Saltman Paul D.
Smith Kenneth T.
Clardy S. Mark
Dabek Rose Ann
Raymond Richard L.
Regents of the University of California
The Procter & Gamble & Company
LandOfFree
Calcium and trace mineral supplements does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Calcium and trace mineral supplements, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Calcium and trace mineral supplements will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1967124