C-phenyl glycitol compound

Details C-phenyl glycitol compound C-phenyl glycitol compound

2011-07-05

2011-07-05

McIntosh, III, Travis C (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S018700, C536S029200

Reexamination Certificate

active

07973012

ABSTRACT:
Provided is a novel C-phenyl glycitol compound that may serve as a prophylactic or therapeutic agent for diabetes by inhibiting both SGLT1 activity and SGLT2 activity, thereby exhibiting a glucose absorption suppression action and a urine glucose excretion action. A C-phenyl glycitol compound represented by Formula (I) below or a pharmaceutically acceptable salt thereof or a hydrate thereofwherein R1and R2are the same or different and represent a hydrogen atom, a hydroxyl group, a C1-6alkyl group, a C1-6alkoxy group or a halogen atom,R3is a hydrogen atom, a C1-6alkyl group, a C1-6alkoxy group or a halogen atom,Y is a C1-6alkylene group, —O—(CH2)n- (n is an integer of 1 to 4) or a C2-6alkenylene group, provided that when Z is —NHC(═NH)NH2or —NHCON(RB)RC, n is not 1,Z is —CONHRA, —NHC(═NH)NH2or —NHCON(RB)RC,

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