Busulfan immunoassay

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S388900, C530S402000, C530S403000, C530S405000, C436S544000, C436S547000, C436S548000, C435S961000

Reexamination Certificate

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07893220

ABSTRACT:
Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids.

REFERENCES:
patent: 5559148 (1996-09-01), Andersson et al.
Lai et al. Routine analysis of plasma busulfan by gas chromatograp0hy-mass fragmentography. Clinical Chemistry 1998, vol. 44, No. 12, pp. 2506-2510.
Murdter et al. Sensitive and rapid quantificaiton of Busulfan in small plasma volumes by liquid chromatography-electrospray mass spectrometry. Clinical Chemistry 2001, vol. 47, No. 8, pp. 1437-1442.

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