Broad-spectrum tumor suppressor genes gene products and methods

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424 931, 424 932, 424 9321, 424 936, 424 937, 4353201, 435440, 435455, 435456, 435458, A01N 4304, A61N 6300, C12N 510, C12N 1509

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059122366

ABSTRACT:
The present invention relates to a broad-spectrum tumor suppressor gene and the protein expressed by that gene in appropriate host cells. The protein is a second in-frame AUG codon-initiated retinoblasoma protein of about 94 kD relative molecular mass. The present invention also relates to methods of treating a mammal having a disease or disorder characterized by abnormal cellular proliferation, such as a tumor or cancer and methods of treating abnormally proliferating cells, such as tumor or cancer cells. Treatment is accomplished by inserting a host cell compatible p94.sup.RB expression vector or an effective amount of p94.sup.RB protein into a cell or cells in need of treatment.

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