Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-04-25
2009-12-15
Henley, III, Raymond J (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S370000
Reexamination Certificate
active
07632813
ABSTRACT:
The present invention relates to an agent for increasing BMD characterized by use of a cathepsin K inhibitor as a bone resorption inhibitor in combination with a type of PTH as a bone formation stimulator. This agent for increasing BMD is useful for the treatment of osteoporosis, bone fracture, arthritis, rheumatoid arthritis, osteoarthritis, hypercalcemia, osteometastasis of carcinoma, periodontal disease, bone Paget's disease and other bone metabolic diseases. For example, as the cathepsin K inhibitor, there can be mentioned a compound of formula (W) and a salt thereof, etc.
REFERENCES:
patent: 2004/0235728 (2004-11-01), Stoch et al.
patent: WO 03/013518 (2003-02-01), None
patent: WO 03/039534 (2003-05-01), None
patent: WO 03/091202 (2003-11-01), None
Tatsumoto, Toshio “Kotsusoshosho Chiryo no Genjo to Tenbo”, Igaku no Ayumi, 2001, p. 617-620, vol. 198, No. 9.
Stroup, George B. et al., “Potent and selective inhibition of human cathepsin K leads to inhibition of Bone resorption in vivo in a nonhuman primate”, Journal of Bone and Mineral Research, 2001 p. 1739-1746, vol. 16, No. 10.
Kawada Naoki
Kayasuga Ryouji
Mori Hiroshi
Ochi Yasuo
Tanaka Makoto
Henley, III Raymond J
Ono Pharmaceutical Co. Ltd.
Sughrue & Mion, PLLC
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