Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Patent
1979-06-25
1982-02-02
Love, Ethel G.
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
210638, A01N 102
Patent
active
043140254
ABSTRACT:
Method and apparatus for continuous pH control of aqueous liquid systems, particularly biological and biochemical systems, by sorption of H.sup.+ and/or OH.sup.- ions with a passive ion acceptor material isolated from, but in contact with liquid of said system in a selectively permeable membrane packet. Liquid systems of interest are those with an initial pH in the range of from about 4.5 to 9.0, and the pH of the system is maintained by the invention at its initial value, or brought within, and maintained in, the range of from about 6.5 to 8.0. The ion acceptor material is selected from an inorganic, relatively water insoluble metal oxide, hydroxide, phosphate or silicate matrix which matrix is capable of maintaining a quasi-equilibrium pH state with the aqueous liquid system of interest. The matrixing metals are preferably selected from Ti, Al and B. The matrices may be doped with oxides or hydroxides of Mg, Ca, Zn, Fe, Cu, Co, Cr and V to permit predetermined selection of a desired quasi-equilibrium pH value, and to adjust effective base capacity. Cation (e.g., Na.sup.+ and K.sup.+) doping may be used to expand the matrix lattice structure and help maintain electric (ionic) neutrality. Typical matrix acceptor compounds are selected from Al.sub.2 O.sub.3, anhydrous Al(OH).sub.3, Al(OH).sub.3 gel (preferred), MgHPO.sub.4, and Mg.sub.2 Si.sub.3 O.sub.8. Depending on the materials and dopants used, the matrix acceptors can act either as a weak base or a weak acid. Most importantly the ability of the invention to maintain the pH of surrounding aqueous systems between 6.5 and 8.0 in a non-toxic, non-interfering fashion fills a gap in the present state of the art by achieving effective "buffering" in a range often unobtainable suitably by any other means. The matrix acceptor materials can maintain their initial state even after absorbing up to one-third their stoichiometric equivalent of H.sup.+ and/or OH.sup.- ion. The hydrogen acceptor, e.g., in packet form, is also useful for continuous H.sup.+ or OH.sup.- sorption and pH control for other liquid systems, such as organic and inorganic reactions, fermentation processes, enzymatic reactions, organ storage, and tissue and culture growth, MgCl.sub.2 added to the hydrogen acceptor packet unit further improves blood preservation during storage. New blood anticoagulant Mg.sup.+2 ion containing solutions are disclosed.
REFERENCES:
patent: 3629071 (1971-12-01), Sekhar
patent: 3847738 (1974-11-01), Brake et al.
patent: 4061537 (1977-12-01), Seiler et al.
Love Ethel G.
SBR Lab Inc.
LandOfFree
Blood preservation anticoagulant solution does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Blood preservation anticoagulant solution, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Blood preservation anticoagulant solution will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1821875