Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2010-06-28
2011-12-06
Aulakh, Charanjit (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C546S022000, C435S183000
Reexamination Certificate
active
08071573
ABSTRACT:
Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such asLeishmania majorfarnesyl diphosphate synthase (FPPS) inhibition,Dictyostelium discoideumgrowth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.
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Chan Julian M. W.
Oldfield Eric
Sanders John M.
Song Yongcheng
Zhang Yonghui
Aulakh Charanjit
Greenlee Sullivan P.C.
The Board of Trustees of the University of Illinois, a Body Corp
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