Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-01-24
2010-06-22
Chu, Yong (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S202000, C548S203000, C548S204000
Reexamination Certificate
active
07741348
ABSTRACT:
The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.
REFERENCES:
patent: 98/31687 (1998-07-01), None
patent: WO 00/56724 (2000-03-01), None
patent: 00/56724 (2000-09-01), None
Cited ref—STN—11886593—preliminary—04282009.
Woodburn et al., Journal of Organic Chemistry (1954), 19, p. 863-867.
Cao et al., Synthetic Metals (2005), 148(3), p. 219-226.
STN-11886593B-core structure-08122009.
Chemische Berichte, 1963, vol. 96, p. 438-41.
Kaiser et al. “X-ray structures and ab initio study of the conformational properties of novel oxazole and thiazole containing di- and tripeptide mimetics” J. Chem. Soc. Perkin Trans. 2:1081-1085 (2000).
Li et al. “Synthesis of a directly connected thiazole-oxazole ring system present in microcin B17” J. Org. Chem. 61:778-780 (1996).
Videnov et al. “Synthesis of naturally occurring, conformationally restricted oxazaole and thiazole containing di- and tripeptide mimetics” Angewandte Chemie, International Ed. in English 35:1503-1506 (1996).
Kaiser et al., “X-Ray structures and ab initio study of the conformational properties of novel oxazole and thiazole containing di- and tripeptide mimetics,” J. Chem. Soc., Perkin Trans. 2 (2000), (5), 1081-1085, compound 8.
Videnov et al., “Synthesis of naturally occurring, conformationally restricted oxazole- and thiazole-containing di- and tripeptide mimetics,” Angewandte Chemie, International Edition in English (1996), 35 (13/14), 1503-1506, compounds 16-17.
Li et al., “Synthesis of a Directly Connected Thiazole-Oxazole Ring System Present in Microcin B17,” Journal of Organic Chemistry (1996), 61(2), 778-80, compound 8.
Wang et al., “First total synthesis of Leucamide A,” Journ. of organic chemistry 68 (4): 1636-1639, Feb. 21, 2003, compounds 4, 8 and 9.
Wang et al., “Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents,” Bioorganic & Medicinal Chemistry Letters, Dec. 1, 2005, 15(23), 5284-5287, the whole document.
International Search Report for PCT/CN2006/000124 mailed May 18, 2006.
International Search Report; PCT/CN2006/000124; 7 pages.
“Synthesis of Naturally Occurring, Conformationally Restricted oxazole- and thiazole-containing di- and tripeptide Mimetics”; Videnov, Georgi et al.; Angewandte Chemie, International Edition in English (1996), 35 (13/414), 1503-1506, pp. 1503-1506.
“X-Ray structures and ab initio study of the conformational properties of novel oxazole and thiazole containing di- and tripeptide mimetics”; Kaiser, Dietmar et al.; J. Chem. So., Perkin Trans. 2 (2000), pp. 1081-1085.
“Synthesis of a Directly Connected Thiazole-Oxazole Ring System Present in Microcin B17”; Li, Gang et al.; J. Org. Che., 1996, 61, pp. 778-780.
“First Total Synthesis of Leucamide A”; Wang Wenlong et al.; J. Org. Chem., 2003, 68, pp. 1636-1639.
“Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents”; Wang Wen-Long et al.; Bioorganic & Medicinal Chemistry Letters 2005; pp. 5284-5287.
Chen Haijun
He Peilan
Nan Fajun
Wang Guifeng
Wang Wenlong
Chu Yong
Nixon & Vanderhye P.C.
Shanghai Institute of Materia Medica Chinese Academy of Science
LandOfFree
Bisheterocycle tandem compounds useful as antiviral agents,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bisheterocycle tandem compounds useful as antiviral agents,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bisheterocycle tandem compounds useful as antiviral agents,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4185504