Bisamine bisthiol radiolabel binding moieties

Details Bisamine bisthiol radiolabel binding moieties Bisamine bisthiol radiolabel binding moieties

1995-06-06

2000-07-25

Dees, Jose' G.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 424 165, 534 14, A61K 5100, A61M 3614

Patent

active

060933836

ABSTRACT:
This invention relates to bisamine bisthiol radiolabel binding moieties and synthetic methods therefor. Specifically, the invention provides radiolabel binding moieties that form an electrically neutral complex with technetium-99m.

REFERENCES:
patent: 4434151 (1984-02-01), Byrne et al.
patent: 4444690 (1984-04-01), Fritzberg et al.
patent: 4571430 (1986-02-01), Byrne et al.
patent: 4575556 (1986-03-01), Byrne et al.
patent: 4615876 (1986-10-01), Troutner et al.
patent: 4638051 (1987-01-01), Burns et al.
patent: 4673562 (1987-06-01), Davison et al.
patent: 4832940 (1989-05-01), Ege
patent: 4861869 (1989-08-01), Nicolotti et al.
patent: 4965392 (1990-10-01), Fritzberg et al.
patent: 4986979 (1991-01-01), Morgan, Jr. et al.
patent: 4988496 (1991-01-01), Srinivasan et al.
patent: 5061641 (1991-10-01), Shocat et al.
patent: 5175343 (1992-12-01), Fritzberg et al.
patent: 5242679 (1993-09-01), Fritzberg et al.
patent: 5248764 (1993-09-01), Flanagan et al.
patent: 5279811 (1994-01-01), Bergstein et al.
patent: 5302370 (1994-04-01), Neumeier et al.
patent: 5431900 (1995-07-01), Bergstein et al.
patent: 5443816 (1995-08-01), Zamora et al.
patent: 5480970 (1996-01-01), Pollack et al.
patent: 5508020 (1996-04-01), Dean et al.
patent: 5552525 (1996-09-01), Dean
Bryson et al., "Neutral Technetium(V) Complexes with Amide-Thiol-Thioether Chelating Ligands," Inorg. Chem. 27:2154-2161 (1988).
Bryson et al., "Protecting Groups in the Preparation of Thiolate Complexes of Technetium," Inorg. Chem. 29:2948-2951 (1990).
Childs et al., "Optimum conditions for Labeling of DTPA-Coupled Antibodies with Technetium-99m," J. Nucl. Med. 26:293-299 (1985).
Davison et al., "The Chemistry of Technetium (V)," Int. J. Appl. Radiat. Isotop. 33: 875-881 (1982).
Fischman et al., "A Ticket to Ride: Peptide Radiopharmaceuticals," J. Nucl. Med. 34(12): 2253-2263 (1993).
Hnatowich et al., "Radioactive Labeling of Antibody: A Simple and Efficient Method," Science 220:613-615 (1983).
Misra et al., 1989, "Synthesis of a Novel Diaminodithiol Ligand for Labeling Proteins and Small Molecules with Technetium-99m," Tet. Let. 30:1885-1888.
Paik et al., "The Labeling of High Affinity Sites of Antibodies with Technetium-99m," Int. J. Nucl. Med. Biol. 12:3-8 (1985).
Pearson et al., "Thrombus Imaging Using Technetium-99m-Labeled High-Potency GPIIb/IIIa Receptor Antagonists. Chemistry and Initial Biological Studies," J. Med. Chem. 39(7): pp. 1372-1382 (1996).
Rhodes et al., "Technetim-99m Labeling of Murine Monoclonal Antibody Fragments," J. Nucl. Med. 27:685-693 (1986).
Sundrehagen, "Formation of a [.sup.99m Tc]Polypeptide Hormone: Characterization and Chemical Quality Control by Ampholyte Displacement Radiochromatography," Int. J. Appl. Rad. Isot. 34:1003 (1983).
Taylor et al., "Brain Uptake and Retention of [Tc-99m]T691: A Potential New Tracer of Local Cerebral Blood Flow," J Nucl. Med. 31:885 (1990).
Tubis et al., "The Preparation of .sup.99m Technetium-Labeled Cystine, Methionine and a Synthetic Polypeptide and their Distribution in Mice," Int. J. Appl. Rad. Isot. 19:835-840 (1968).
Zubay, "Proteins: An Overview," Biochemistry, Protein Structure and Function, pp. 3-7 (1983).
Baidoo et al. (1990). Bioconjugate Chem. vol. 1, pp 132-137. Synthesis of a Diaminedithiol Bi functional Chelating Agent for Incorporation of Technetium -99m into Biomolecules.

Affiliated with

Also associated with

Rating

Bisamine bisthiol radiolabel binding moieties does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bisamine bisthiol radiolabel binding moieties, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bisamine bisthiol radiolabel binding moieties will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1334585