Bis-esters of dicarboxylic acids with amoxicillin and certain hy

Details Bis-esters of dicarboxylic acids with amoxicillin and certain hy Bis-esters of dicarboxylic acids with amoxicillin and certain hy

1983-03-31

1984-07-31

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424271, C07D49948

Patent

active

044629346

ABSTRACT:
Antibacterial bis-esters of 1,4-cyclohexanedicarboxylic acids and alkane dicarboxylic acids wherein the ester moieties are derived from different alcohols; one alcohol being hydroxymethylpenicillanate 1,1-dioxide, or the 6-beta-hydroxymethyl or the 6-alpha-aminomethyl derivative thereof; and the other being 6-[D-(2-amino-2-(p-hydroxyphenyl)acetamido)]penicillanic acid (amoxicillin); and pharmaceutically acceptable salts thereof; a method for the use of said esters and their salts, and methods for their preparation.

REFERENCES:
patent: 4234579 (1980-11-01), Barth
patent: 4244951 (1981-01-01), Bigham
patent: 4342768 (1982-08-01), Kellogg
patent: 4342772 (1982-08-01), Godtfredsen
patent: 4377590 (1983-03-01), Myers

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